8.A.37 The Hepcidin (Hepcidin) Family
Hepcidin is known to increase intracellular iron through binding to and degrading ferroportin, which is a transmembrane protein that transports iron from the cytoplasm to the outside. Hepcidin (<100 nM/L) increases intracellular calcium when cells are exposed to high environmental iron concentrations (Li et al., 2012). L-type calcium channel, and ryanodine receptors are not involved. Antagonists of these channels inhibit abnormal calcium release from the sarco-endoplasmic reticulum. The increase of intracellular calcium induced by hepcidin is probably due to calcium release from the endoplasmic reticulum.
Hepcidin of Mus musculus (Q9EQ21)
Human hepcidin (84 aas). Binds to and inhibits ferroportin (TC#2.A.100.1.4) (Le Gac et al. 2013). Causes ferroportin internalization and degradation (Rice et al. 2009).
Hepcidin of Homo sapiens
Hepcidin antimicrobial peptide 4 of 95 aas.
Hepcidin peptide of Pagrus auriga
Hepcidin-like protein of 81 aas
Hepcidin-like protein of Python bivittatus
Uncharacterized protein of 111 aas.
UP of Quercus suber