8.B.39.  The Conotoxin K (CoTxJ) Family 

Some of these toxins induce excitatory symptoms in mice following intracranial administration.

This family belongs to the .



Ye, M., K.K. Khoo, S. Xu, M. Zhou, N. Boonyalai, M.A. Perugini, X. Shao, C. Chi, C.A. Galea, C. Wang, and R.S. Norton. (2012). A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. J. Biol. Chem. 287: 14973-14983.


TC#NameOrganismal TypeExample

Conotoxin im23.3 of 70 aas and 1 TMS.  It is a neurotoxin that induces excitatory symptoms in mice following intracranial administration (Ye et al. 2012). The 3-d structure of a 42 aa seqence from a similar conotoxin, conotoxin im17.a from the same organism, has been solved (PDB acc# 2LMZ).

CoTx im23.3 of Conus imperialis


Uncharacterized protein of 100 aas and 1 N-terminal TMS.

UP of Bathymodiolus septemdierum thioautotrophic gill symbiont