8.B.8 The α-KTx15 Scorpion Toxin (α-KTx15) Family

Discrepin is a scorpion peptide that blocks preferentially the I(A) currents of the voltage-dependent K(+) channel of rat cerebellum granular cells. It was isolated from the venom of the buthid scorpion Tityus discrepans and contains 38 amino acid residues with a pyroglutamic acid at the N-terminal site. Discrepin has the lowest sequence identity (approx. 50%) among the six members of the α-KTx15 sub-family of scorpion toxins (Romeo et al., 2008).



This family belongs to the .

 

References:

Huys, I., C.Q. Xu, C.Z. Wang, H. Vacher, M.F. Martin-Eauclaire, C.W. Chi, and J. Tytgat. (2004). BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochem. J. 378: 745-752.

Prochnicka-Chalufour, A., G. Corzo, H. Satake, M.F. Martin-Eauclaire, A.R. Murgia, G. Prestipino, G. D'Suze, L.D. Possani, and M. Delepierre. (2006). Solution structure of discrepin, a new K+ -channel blocking peptide from the α- KTx15 subfamily. Biochemistry. 45: 1795-1804.

Romeo, S., G. Corzo, A. Vasile, H. Satake, G. Prestipino, and L.D. Possani. (2008). A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the I(A) currents in cerebellum granular cells. Biochim. Biophys. Acta. 1780: 750-755.

Examples:

TC#NameOrganismal TypeExample
8.B.8.1.1Discrepin (K+ channel toxin α-KTx15.6) (solution structure solved (2AXK_A); Prochnicka-Chalufour et al., 2006)ScorpionsDiscrepin of Tityus discrepans (P84777)
 
8.B.8.1.2Tx3 toxin; active on A-type K+ and HERG currents (Huys et al., 2004)ScorpionsTx3 of Buthus (Mesobuthus) martensii (Q8I0L5)
 
8.B.8.1.3

Margatoxin MgTx; Toxin Ce; K+ channel toxin α-KTx of 39 aas.  Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes but not Ca2+-activated K+ channel

Animals

MgTx of Centruroides elegans (bark scorpion)

 
8.B.8.1.4

K+ channel toxin 2.11 of 39 aas; also called Toxin Ce4.  

Animals

Ce4 of Centruroides elegans

 
8.B.8.1.5

Matentoxin-1 of 59 aas.

Animals

Matentoxin-1 of Mesobuthus martensii

 
8.B.8.1.6

Putative K+ channel inhibitor, αKTx30.3; SjKTx51

Animals

KTx51 of Scorpiops jendeki

 
Examples:

TC#NameOrganismal TypeExample