9.A.22 The Putative Bacillus Transporter of Unknown Function (BTUF) Family
A single 6 TMS protein, originally termed NhaE of Bacillus pseudofirmus OF4, had been reported in TCDB as an exchanger of H+ for either Na+ or K+ , but the results were not reproduced and a paper was not published. Members of this family are therefore of unknown function.
The NhaE Na+/K+:H+ antiporter. The gene encoding this protein is adjacent to genes encoding a GntR transcriptional regulator, two ABC ATPases designated NatA1 and NatA2 and an ABC membrane protein designated NatB, all possibly within an single operon.
NhaE (orf 14) of Bacillus pseudofirmus
Hypothetical protein. The encoding gene is adjacent to genes encoding a GntR transcriptional regulator (Q9KDP7), two ABC ATPases (Q9KDP6 and 7) and a putative ABC membrane protein (Q9KDP5), all possibly in a single operon.
HP of Bacillus halodurans
Hypothetical protein. Encoded by a gene adjacent to genes encoding a GntR transcriptional regulator, a similar membrane protein with 6 TMSs in a 2 + 4 arrangement, followed by two genes encoding two ABC ATPases annotated as NatA1 and A2, followed by a membrane protein annotated as NatB2. These genes may all be in a single operon.
HP of Bacillus cellulosilyticus
Uncharacterized protein of 241 aas and 6 TMSs.
UP of Alkalibacillus haloalkaliphilus
HP of Bacillus clausii
Hypothetical 6 TMS protein. Clearly a member of the 9.A.22 family, but also exhibits sequence similarity to the second half (TMSs 7 - 12) of the MFS permease, 2.A.1.62.3.
HP of Paenibacillus terrae
Uncharacterized protein of 235 aas and 6 TMSs.
UP of Thermoactinomyces sp. DSM 45892
Uncharacterized protein of 249 aas and 6 TMSs.
UP of Salinibacillus kushneri
Uncharacterized protein of 237 aas and 6 TMSs.
UP of Chryseobacterium gleum
Uncharacterized protein of 224 aas and 6 TMSs
UP of Sphingopyxis sp. MC1
Uncharacterized protein of 229 aas and 6 TMSs
UP of Ensifer adhaerens (Sinorhizobium morelense)