9.A.22 The Putative Bacillus Transporter of Unknown Function (BTUF) Family

A single 6 TMS protein, originally termed NhaE of Bacillus pseudofirmus OF4, had been reported in TCDB as an exchanger of H+ for either Na+ or K+ , but the results were not reproduced and a paper was not published. Members of this family are therefore of unknown function.



This family belongs to the .

Examples:

TC#NameOrganismal TypeExample
9.A.22.1.1

The NhaE Na+/K+:H+ antiporter.  The gene encoding this protein is adjacent to genes encoding a GntR transcriptional regulator, two ABC ATPases designated NatA1 and NatA2 and an ABC membrane protein designated NatB, all possibly within an single operon.

Bacteria

NhaE (orf 14) of Bacillus pseudofirmus

 
9.A.22.1.2

Hypothetical protein.  The encoding gene is adjacent to genes encoding a GntR transcriptional regulator (Q9KDP7), two ABC ATPases (Q9KDP6 and 7) and a putative ABC membrane protein (Q9KDP5), all possibly in a single operon.

Firmicutes

HP of Bacillus halodurans

 
9.A.22.1.3

Hypothetical protein.  Encoded by a gene adjacent to genes encoding a GntR transcriptional regulator, a similar membrane protein with 6 TMSs in a 2 + 4 arrangement, followed by two genes encoding two ABC ATPases annotated as NatA1 and A2, followed by a membrane protein annotated as NatB2.  These genes may all be in a single operon.

Firmicutes

HP of Bacillus cellulosilyticus

 
9.A.22.1.4

Uncharacterized protein of 241 aas and 6 TMSs.

UP of Alkalibacillus haloalkaliphilus

 
Examples:

TC#NameOrganismal TypeExample
9.A.22.2.1

Hypothetical protein

Firmicutes

HP of Bacillus clausii

 
Examples:

TC#NameOrganismal TypeExample
9.A.22.3.1

Hypothetical 6 TMS protein.  Clearly a member of the 9.A.22 family, but also exhibits sequence similarity to the second half (TMSs 7 - 12) of the MFS permease, 2.A.1.62.3.

Firmicutes

HP of Paenibacillus terrae

 
9.A.22.3.2

Uncharacterized protein of 235 aas and 6 TMSs.

UP of Thermoactinomyces sp. DSM 45892

 
9.A.22.3.3

Uncharacterized protein of 249 aas and 6 TMSs.

UP of Salinibacillus kushneri

 
Examples:

TC#NameOrganismal TypeExample
9.A.22.4.1

Uncharacterized protein of 237 aas and 6 TMSs.

UP of Chryseobacterium gleum

 
9.A.22.4.2

Uncharacterized protein of 224 aas and 6 TMSs

UP of Sphingopyxis sp. MC1

 
9.A.22.4.3

Uncharacterized protein of 229 aas and 6 TMSs

UP of Ensifer adhaerens (Sinorhizobium morelense)