9.A.50 The Nuclear t-RNA Exporter (t-Exporter) Family
tRNAs are made in the nucleolus of the nuclei of eukaryotes. They are processed and exported into the cytoplasm. The t-exporter consists of several proteins. The protein t-UTP8 acts between maturation and translocation across the nuclear pore complex. It interacts with the two tRNA export receptors, Los1 and Msn5, and the Ran GTPase, Gsp1 t-UTP8, probably transfers tRNA to the nuclear tRNA export receptors by using a channeling mechanism (Strub et al., 2007).
The transport reaction catalyzes by the t-exporter is:
tRNA (nucleus) → tRNA (cytoplasm)