9.A.61 The Domain of Unknown Function 3339 (DUF3339) Family
The DUF3339 domain is 68 aas in length. It is predicted to contain two transmembrane domains of 20 and 23 residues each but no cleavable signal peptide. Interestingly, several virus sequences have two tandem copies of the gene (4 predicted TMSs), and several larger proteins (enzymes; structural and regulatory proteins) have the DUF3339 domain either N- or C-terminal to the rest of these proteins. Representative sequences of the protein itself ((9.A.61.1.1 - 1.3) or fused structures (9.A.61.2.1 and 3.1) as well as duplicated viral proteins with 4 TMSs (9.A.61.4.1) are included as family members. Most if not all family members are derived from plants and related organisms.
DUF3339 protein of 69 aas and 2 TMSs.
DUF3339 protein of Arabidopsis thaliana (Mouse-ear cress)
Uncharacterized protein of 142 aas and 4 TMSs.
UP of Arabidopsis thaliana (Mouse-ear cress)
Uncharacterized protein of 68 aas and 2 TMSs
UP of Prunus persica (Peach) (Amygdalus persica)
Katanin p80 WD40 repeat-containing subunit B1 homologue of 823 aas and 2 TMSs (N-terminal). May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. This protein has at least 4 repeats of about 42 aass (WD40). The protein is an AAA ATPase which targets centrosomes (Hartman et al. 1998). p80 katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein (McNally et al. 2000).
Katanin of Arabidopsis thaliana (Mouse-ear cress)
Peroxidase of 368 aas and 2 C-terminal TMSs
Peroxidase of Brassica rapa (Chinese cabbage) (Brassica pekinensis)
Uncharacterized protein of 130 aas and 4 TMSs.
UP of Ostreococcus tauri virus RT-2011