9.B.131  The Post-GPI Attachment Protein (P-GAP2) Family

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that serves as a membrane anchor for many cell-surface proteins, such as Thy-1 and CD48. GPI-anchored proteins (GPI-APs) play important roles in many biological processes, such as signal transduction and cell-cell interaction, through their association with lipid rafts. Fatty acid remodeling of GPI-APs in the Golgi apparatus is required for their efficient association with lipid rafts, i.e., the unsaturated fatty acid at the sn-2 position of the PI moiety is exchanged for the saturated fatty acid by PGAP2 and PGAP3 (Murakami et al., 2012).

This family belongs to the .



Murakami, H., Y. Wang, H. Hasuwa, Y. Maeda, T. Kinoshita, and Y. Murakami. (2012). Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins. Biochem. Biophys. Res. Commun. 417: 1235-1241.


TC#NameOrganismal TypeExample

Protein CWH43 (Calcofluor white hypersensitive protein). Possibly 21 TMSs in a 7x3 arrangement.

FungiCWH43 of Saccharomyces cerevisiae

The Post-GPI attachment protein factor 2, P-GAP2.  (7 putative TMSs)


P-GAP2 of Homo sapiens


Post-PGI attachment protein, factor 2


P-GAP, factor 2 of Caenorhabditis elegans


Uncharacterized protein of 683 aas and 13 TMSs.

UP of Candidatus Heimdallarchaeota archaeon AB_125 (marine sediment metagenome)


Uncharacterized protein of 618 aas and 13 TMSs

UP of Chloroflexi bacterium


Uncharacterized protein of 621 aas and 13 TMSs.

UP of Chloroflexi bacterium


Uncharacteerized protein of 620 aas and 13 TMSs

UP of Anaerolineae bacterium SM23_ 63


Uncharacterized protein of 452 aas and 12 TMSs.

UP of Lokiarchaeum sp. GC14_75


TC#NameOrganismal TypeExample