9.B.19 The Plasmodium Early Transcribed Ring Stage Membrane Protein (ETRAMP) Family

The early transcribed membrane proteins (ETRAMPs) are a family of small, highly charged transmembrane proteins unique to malaria parasites. Some members of the ETRAMP family have been localized to the parasitophorous vacuole membrane that separates the intracellular parasite from the host cell and thus presumably have a role in host-parasite interactions. Although it has been shown that two ETRAMPs are critical for rodent malaria parasite liver-stage development, the importance of most ETRAMPs during the parasite life cycle remains unknown. MacKellar et al. 2011 identified nine ETRAMPs in the genome of the rodent malaria parasite Plasmodium yoelii, and elucidate their conservation in other malaria parasites. etramp expression profiles are diverse throughout the parasite life cycle. Protein expression occurs in blood and liver stages with differences in both their timing of expression and their subcellular localizations. Gene targeting studies of each of the nine uncharacterized ETRAMPs showed that two are refractory to deletion and thus may be essential for blood-stage replication. Seven ETRAMSs are not essential for any life cycle stage. Systematic characterization of the members of the ETRAMP family revealed the diversity of the family members at the interface between host and parasite throughout the developmental cycle of the malaria parasite.

This family belongs to the .



Currà, C., M. Di Luca, L. Picci, C. de Sousa Silva Gomes dos Santos, I. Siden-Kiamos, T. Pace, and M. Ponzi. (2013). The ETRAMP family member SEP2 is expressed throughout Plasmodium berghei life cycle and is released during sporozoite gliding motility. PLoS One 8: e67238.

MacKellar, D.C., A.M. Vaughan, A.S. Aly, S. DeLeon, and S.H. Kappe. (2011). A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii. Cell Microbiol 13: 1755-1767.

Vignali, M., A. McKinlay, D.J. LaCount, R. Chettier, R. Bell, S. Sahasrabudhe, R.E. Hughes, and S. Fields. (2008). Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins. Malar J 7: 211.


TC#NameOrganismal TypeExample

Plasmodium ring stage membrane protein, ETRAMP, of 106 aas and 2 TMSs, the first being the signal peptide, and the other a typical TMS in this mature highly charged protein.  These proteins interact with host lipoproteins (Vignali et al. 2008).


ETRAMP protein of Plasmodium falciparum


Small exported protein 2, SEP2, of 151 aas and 2 TMSs.  It is present throughout the parasite life cycle and is released during gliding motility of salivary gland sporozoites. (Currà et al. 2013).


SEP2 of Plasmodium berghei


ETRAMP family member of 127 aas and 2 TMSs.


ETRAMP family member of Plasmodium cynomolgi


ETRAMP famiy protein of 208 aas and 2 TMSs.


ETRAMP family member of Plasmodium vivax