9.B.199 The 4 TMS PF05225 (PF0225) Family
The PF05225 family consists of uncharacterized 4 TMS proteins containing the conserved Pfam domain UPF0220 (Attwood et al. 2016). Some members of the family appear to be involved in vacuolar protein trafficking in yeast (Schluter et al. 2008). Additionally, targeted degradation of integral membrane proteins is ensured by a complex network of proteins, among which the endosomal sorting complex required for transport (ESCRT) plays a central role (Isono and Kalinowska 2017) (see 9.B.199.1.7).
Uncharacterized TMEM50A protein of 157 aas and 4 TM
TMEM50A of Homo sapiens
The TMEM50B or TM255B protein of 158 aas and 4 TMSs.
TMEM50B of Homo sapiens
Transmembrane protein 50A, TMEM50A of 135 aas and 4 TMSs
TMEM50A of Medicago truncatula (Barrel medic) (Medicago tribuloides)
Transmembrane protein with UPF0220 domain of 173 aas and 4 TMSs.
UPF0220 domain-containing protein of Aspergillus clavatus
Vacuolar sorting protein, Vps68 of 170 aas and 4 TMSs (Künzl et al. 2016).
Vps68 of Schizosaccharomyces pombe (Fission yeast)
Uncharacterized protein of 141 aas and 4 TMSs
UP of Leishmania braziliensis
Vacuolar protein sorting-associated protein 68, Vps68, of 184 aas and 4 TMSs. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking. Loss of Vps68p disrupts recycling to the trans-Golgi network (TGN) as well as onward trafficking to the vacuole without preventing the formation of lumenal vesicles (Schluter et al. 2008).
Vps68 of Saccharomyces cerevisiae (Baker's yeast)
Uncharacterized protein of 218 aas and 4 TMSs.
UP of Guillardia theta