9.B.225. The Mannosyl Transferase (MptB) Family
The MtpB (formerly the DUF2029) family consists of many proteins which are sometimes annotated as DUF2029 or as mannosyltransferases. MtpB of Corynebacterium glutamicum has been characterized (Rainczuk et al. 2012). These proteins show weak similarity with members of the glycosyltransferase (GT39) family (TC# 9.B.142). These two families may be related. It is not known if these transferases transport their carbohydrate substrates across the membrane.
Estabilshed α-1,6 mannosyltransferase B, MptB of 602 aas and 11 TMSs. Involved in the initiation of core alpha-(1,6) mannan biosynthesis of lipomannan (LM-A) and multi-mannosylated polymer (LM-B), extending triacylatedphosphatidyl-myo-inositol dimannoside (Ac1PIM2) and mannosylated glycolipid, 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1->4)-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol (Man1GlcAGroAc2), respectively. Catalyzes the addition of alpha-(1->6)-mannosyl residues (Rainczuk et al. 2012).
MptB of Corynebacterium glutamicum
Uncharacterized DUF2029 domain protein of 521 aas and 11 TMSs.
UP of Nakamurella lactea
Uncharacterized putative α-1,6 mannosyltransferase of 541 aas and 12 TMSs.
UP of Kibdelosporangium aridum
Uncharacterized DUF2029 domain protein of 475 aas and 11 TMSs.
UP of Solirubrobacter soli
Uncharacterized putative mannosyltransferase of 453 aas and 12 TMSs.
UP of Kriegella aquimaris
Uncharacterized protein of 551 aas and 16 TMSs
UP of Thermogemmatispora carboxidivorans
The uncharacterized DUF2029 domain-containing protein of 438 aas and 11 TMSs.
UP of Lishizhenia tianjinensis
Uncharacterized protein of 424 aas and 10 TMSs
UP of Indibacter alkaliphilus
Uncharacterized protein of 457 aas and 9 putative TMSs. Distantly related to 8.A.95. May be a 4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of the PMT family.
UP of Aeromonas salmonicida