9.B.235.  The Mitochondrial Outer Membrane Protein-14 (Om14) Family  

Proteomics on the outer membrane from yeast mitochondria suggest that most of these mitochondrial proteins have α-helical TMSs. These proteins are usually predicted to have a single α-helical TMS at either the N- or C-terminus, but more complex topologies are also seen. Burri et al. 2006 purified Om14 and found that it probably has 3 TMSs. It is encoded by the gene, YBR230c. Levels of the Om14 protein are much lower in cells grown on glucose than in cells grown on nonfermentable carbon sources. The α-helical outer membrane proteins presumably provide functions derived after the endosymbiotic event and require the translocase in the outer mitochondrial membrane complex (TC# 3.A.8) for membrane  insertion (Burri et al. 2006).

This family belongs to the .



Burri, L., K. Vascotto, I.E. Gentle, N.C. Chan, T. Beilharz, D.I. Stapleton, L. Ramage, and T. Lithgow. (2006). Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae. FEBS J. 273: 1507-1515.


TC#NameOrganismal TypeExample

Functionally uncharacterized mitochondrial outer membrane protein, Om14, of 134 aas and 3 TMSs (Burri et al. 2006).

Om14 of Saccharomyces cerevisiae


Om14 of 160 aas and 3 TMSs.

Om14 of Lachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)


Om14 of 173 aas and 3 TMSs.

Om14 of Kluyveromyces marxianus


Om14 of 189 aas and 3 TMSs.

Om14 of Cyberlindnera fabianii


Om14 of 178 aas and 3 TMSs.

Om14 of Hyphopichia burtonii


Om14 of 182 aas and 3 TMSs.

Om14 of Pichia sorbitophila (Hybrid yeast)


Om14 of 152 aas and 3 TMSs.

Om14 of Yarrowia lipolytica (Yeast) (Candida lipolytica)


Om14 of 176 aas and 2 TMSs.

Om14 of Talaromyces stipitatus (Penicillium stipitatum)


Uncharacterized protein of 180 aas and 2 or 3 C-terminal TMSs.

UP of Malassezia pachydermatis


TC#NameOrganismal TypeExample