9.B.235. The Mitochondrial Outer Membrane Protein-14 (Om14) Family
Proteomics on the outer membrane from yeast mitochondria suggest that most of these mitochondrial proteins have α-helical TMSs. These proteins are usually predicted to have a single α-helical TMS at either the N- or C-terminus, but more complex topologies are also seen. Burri et al. 2006 purified Om14 and found that it probably has 3 TMSs. It is encoded by the gene, YBR230c. Levels of the Om14 protein are much lower in cells grown on glucose than in cells grown on nonfermentable carbon sources. The α-helical outer membrane proteins presumably provide functions derived after the endosymbiotic event and require the translocase in the outer mitochondrial membrane complex (TC# 3.A.8) for membrane insertion (Burri et al. 2006).
Functionally uncharacterized mitochondrial outer membrane protein, Om14, of 134 aas and 3 TMSs (Burri et al. 2006).
Om14 of Saccharomyces cerevisiae
Om14 of 160 aas and 3 TMSs.
Om14 of Lachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Om14 of 173 aas and 3 TMSs.
Om14 of Kluyveromyces marxianus
Om14 of 189 aas and 3 TMSs.
Om14 of Cyberlindnera fabianii
Om14 of 178 aas and 3 TMSs.
Om14 of Hyphopichia burtonii
Om14 of 182 aas and 3 TMSs.
Om14 of Pichia sorbitophila (Hybrid yeast)
Om14 of 152 aas and 3 TMSs.
Om14 of Yarrowia lipolytica (Yeast) (Candida lipolytica)
Om14 of 176 aas and 2 TMSs.
Om14 of Talaromyces stipitatus (Penicillium stipitatum)
Uncharacterized protein of 180 aas and 2 or 3 C-terminal TMSs.
UP of Malassezia pachydermatis