9.B.29 The small 4-5 TMS Putative Permease (4-5PP) Family
The 4-5PP family consists of proteins from Spirochaetes (Leptospira (subfamily 1)) and many potentially distant homologues in other bacteria (subfamilies 2 - 4) as well as archaea (subfamily 5). They have 200 - 270 aas with 4 - 5 TMSs. Some of them are encoded adjacent to genes coding for membrane fusion proteins (MFPs; 8.A.1) and outer menbrane factors (OMFs; 1.B.17) implying they are effulx systems. These proteins may be distantly related to but members of the ABC superfamily (3.A.1).
References:
Uncharacterized protein of 205 aas and 5 TMSs
Spirochaetes
UP of Leptospira interogans
Uncharacterized protein of 204 aas and 5 TMSs
Spirochaetes
UP of Leptospira biflexa
Uncharacterized protein of 231 aas and 5 TMSs.
Firmicutes
UP of Bacillus sp.
Uncharacterized protein of 227 aas and 5 TMSs
Spirochaetes
UP of Leptospira santarosai
Uncharacterized protein of 198 aas and 5 TMSs
Euryarchaea
UP of Methanocorpusculum labreanum
Uncharacterized putative ABC-type transporter with three constituents, one of 194 aas and 5 TMSs (A3U434), one encoding another hydrophobic protein of 161 aas and 4 TMSs (A3U435) and another gene encoding an ABC-type ATPase of 251 aas (SufC; A3U437) in the same gene cluster.
Proteobacteria
Putative ABC efflux transporter of Pseudooceanicola batsensis (Oceanicola batsensis)
Uncharacterized protein of the Pfam Yip1 superfamily. 220 aas and 5 TMSs.
Firmicutes
UP of Caldicellulosiruptor saccharolyticus
Uncharacterized protein of 196 aas and 5 TMSs.
Actinobacteria
UP of Rubrobacter xylanophilus
Uncharacterized protein of 221 aas and 5 TMSs. Also similar to 3.A.1.122.2.
Firmicutes
UP of Carboxydothermus hydrogenoformans
Uncharacterized protein of 267 aas and 5 TMSs with an N-terminal zinc_ribbon_2 domain.
UP of Candidatus Lokiarchaeota archaeon CR_4
Uncharacterized protein of 203 aas and 5 TMSs
Firmicutes
UP of Solibacillus silvestris (Bacillus silvestris)
Uncharacterized protein of 216 aas and 5 TMSs
Firmicutes
UP of Bacillus cereus
Uncharacterized protein of 198 aas and 5 TMSs
Firmicutes
UP of Heliobacterium modesticaldum
Uncharacterized protein of 207 aas and 5 TMSs
Firmicutes
UP of Ammonifex degensii
Uncharacterized protein of 251 aas and 5 TMSs
Firmicutes
UP of Desulfotomaculum carboxydivorans
Uncharacterized protein of 212 aas and 5 TMSs (B8GHI5). The adjacent gene encodes a homologue of 209 aas and 5 TMSs (B8GHI4; e-41), then a 415 aas protein with 2 TMSs, N- and C-terminal (B8GHI3), then an ABC ATPase of 234 aas (B8GHI2), then a type 3 membrane ABC protein of 4 TMSs (B8GHI1) and then an inner membrane PrsW type protease (B8GHI0). B8GHI2 and B8GHI1 appear to comprise an ABC transporter assigned TC# 3.A.1.122.21.
Euryarchaea
UP of Methanosphaerula palustris
Uncharacterized protein of 210 aas and 4 TMSs
Euryarchaea
UP of Methanosarcina barkeri
Uncharacterized protein of 174 aas and 4 TMSs
Euryarchaera
UP of Archaeoglobus fulgidus
Uncharacterized protein of 203 aas and 5 TMSs
Proteobacteria
UP of Pseudomonas fluorescens
Uncharacterized protein of 203 aas and 5 TMSs with UniProt acc# of F9ZP17. F9ZP16 is a Membrane Fusion Protein (MFP: TC#8.A.1) and F9ZP15 is an outer membrane factor (OMF; TC# 1.B.17).
Proteobacteria
UP of Acidithiobacillus caldus
Uncharacterized protein of 199 aas and 5 TMSs
Proteobacteria
UP of Aromatoleum aromaticum
Uncharacterized protein of 386 aas and 5 TMSs
Proteobacteria
UP of Sphingobium sp. SYK-6
Uncharacterized protein of 202 aas and 5 TMSs
Proteobacteria
UP of Alkalilimnicola ehrlichii
Uncharacterized protein of 181 aas and 5 TMSs
Bacteroidetes
UP of Bacteroides ovatus
Uncharacterized protein of 191 aas and 5 TMSs
Deinococcus/Thermus
UP of Deinococcus maricopensis