9.B.61 The Putative Pore-forming Hydrogenosomal Membrane Protein Hmp35 (Hmp35) Family

The abundant, integral membrane Hmp35 hydrogenosomal protein from Trichomonas vaginalis lacks recognizable homologues in the database. It is 319 aas and consists predominantly of β-structure. It exhibits one putative N-terminal TMS and may form oligomeric pores (Dyall et al., 2003).



This family belongs to the .

 

References:

Dyall, S.D., D.C. Lester, R.E. Schneider, M.G. Delgadillo-Correa, E. Plumper, A. Martinez, C.M. Koehler, and P.J. Johnson. (2003). Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria. J. Biol. Chem. 278: 30548-30561.

Huynh, C., X. Yuan, D.C. Miguel, R.L. Renberg, O. Protchenko, C.C. Philpott, I. Hamza, and N.W. Andrews. (2012). Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1. PLoS Pathog 8: e1002795.

Rada, P., P. Doležal, P.L. Jedelský, D. Bursac, A.J. Perry, M. Šedinová, K. Smíšková, M. Novotný, N.C. Beltrán, I. Hrdý, T. Lithgow, and J. Tachezy. (2011). The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis. PLoS One 6: e24428.

Examples:

TC#NameOrganismal TypeExample
9.B.61.1.1

Hydrogenosomal membrane protein-35, Hmp35 (Rada et al. 2011).

Eukaryotic protist

Hmp35 of Trichomonas vaginalis (AAP76310)

 
9.B.61.1.2

Putative β-barrel protein, Hmp36, of 322 aas and 17 predicted transmembrane β-strands.

Hmp36 of Trichomonas vaginalis

 
9.B.61.1.3

Hmp36-2 of 324 aas and 15 predicted transmembrane β-strands (Rada et al. 2011).

Hmp36-2 of Trichomonas vaginalis

 
Examples:

TC#NameOrganismal TypeExample