9.B.82 The  Endoplasmic Reticulum Retrieval Protein1 (Putative Heavy Metal Transporter) (Rer1) Family

Mutations in the gene encoding the 4 TMS (2 + 2) Rer1 protein in S. cerevisiae (of about 190 aas as are most of its homologues) can be complemented by human NRAMP1 (TC# 2.A.55.2.3), suggesting that it might be a heavy metal efflux pump (Techau et al., 2007). It has homologues in many fungi, animals, plants and other eukaryotes, almost all of about 190 aas. Single oraganisms can have multiple paralogues.



This family belongs to the .

 

References:

Techau, M.E., J. Valdez-Taubas, J.F. Popoff, R. Francis, M. Seaman, and J.M. Blackwell. (2007). Evolution of differences in transport function in slc11a family members. J. Biol. Chem. 282: 35646-35656.

Examples:

TC#NameOrganismal TypeExample
9.B.82.1.1Putative heavy metal transporter, Rer1YeastRer1 of Saccharomyces cerevisiae (P25560)
 
9.B.82.1.2Putative heavy metal transporter, Rer1AnimalsRer1 of Homo sapiens (O15258)
 
9.B.82.1.3Arabidopsis thaliana endoplasmic reticulum retrieval protein 1A (ATREA1A or Rer1A)PlantsRer1A of Arabidopsis thaliana (O48670)
 
9.B.82.1.4ER retrieval protein, Rer1ProtozoaRer1 of Trypanosoma cruzi (Q4CLA0)
 
9.B.82.1.5Rer1 homologueCiliateRer1 of Paramecium tetraurelia (A0CS82)
 
Examples:

TC#NameOrganismal TypeExample
9.B.82.2.1Rer1 family-like protein (116 aas; 2 TMSs;l may be a partial sequence)ProtozoaRer1-like protein of Leishmania braziliensis (A4HCA2)