TCDB is operated by the Saier Lab Bioinformatics Group
Transporter Information:
Name: annexin A2 pseudogene 1
Symbol: ANXA2P1
Locations: 4q21-q31
GenBank: M62896
PubMed (1611909): Galland F, Stefanova M, Lafage M, Birnbaum D. Localization of the 5' end of the MCF2 oncogene to human chromosome15q15----q23.Cytogenet Cell Genet. 1992;60(2):114-6. PMID: 1611909 [PubMed - indexed for MEDLINE]

Oncogenic activation of the MCF.2 cell line-derived transforming sequence gene (MCF2) occurs through substitution of part of its 5' coding region by unrelated nonsyntenic sequences. Analysis of the MCF2 oncogene locus revealed complex recombination events involving four discontinuous human DNA segments. The upstream replacing sequence, named URS, represents the farthest 5' portion of the locus. The URS sequence maps to the D15S93 locus on human chromosome 15q15----q23.

PubMed (2174397): Spano F, Raugei G, Palla E, Colella C, Melli M. Characterization of the human lipocortin-2-encoding multigene family: itsstructure suggests the existence of a short amino acid unit undergoingduplication.Gene. 1990 Nov 15;95(2):243-51. PMID: 2174397 [PubMed - indexed for MEDLINE]

Human genomic clones of the gene encoding lipocortin (LIP) 2 (p36) and of three pseudogenes have been isolated and characterized. The LIP2 gene is at least 40 kb long and consists of 13 exons. The three pseudogenes present typical features of retroposons and, together with the gene, probably represent the entire LIP2 multigene family. Chromosomal assignment of the four loci is proposed. The hypothesis that an ancestral unit coding for 15 to 20 amino acids may have been involved in the evolution of the gene is discussed.