TCDB is operated by the Saier Lab Bioinformatics Group
Transporter Information:
Name: annexin A4
Symbol: ANXA4
TC: 1.A.31.1.1
Locations: 2p13
GenBank: M82809
Swiss-Prot: P09525
Accession Number: NM_001153
PubMed (1346776): Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM. Chromosomal mapping of the human annexin IV (ANX4) gene.Genomics. 1992 Feb;12(2):313-8. PMID: 1346776 [PubMed - indexed for MEDLINE]

Annexin IV (placental anticoagulant protein II) is a member of the annexin or lipocortin family of calcium-dependent phospholipid-binding proteins. A cDNA for human annexin IV was isolated from a placental library that is 675 bases longer in the 3' untranslated region than previously reported, indicating the existence of alternative mRNA processing for this gene. Genomic Southern blotting with a cDNA probe indicated a gene size of 18-56 kb. Primers developed for polymerase chain reaction (PCR) allowed amplification of a 1.6-kb portion of the ANX4 gene. DNA sequence analysis showed that this PCR product contained a single intron with exon-intron boundaries in exactly the same position as in the mouse annexin I and annexin II genes. PCR analysis of a somatic cell hybrid panel mapped the ANX4 gene to chromosome 2, and in situ hybridization with a cDNA probe showed a unique locus for ANX4 at 2p13. This study provides further evidence that genes for the annexins are dispersed throughout the genome but are similar in size and exon-intron organization.