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Transporter Information:
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Symbol: ATP1A4
TC: 3.A.3.1.1
Locations: 1q21-q23
Aliases: HGNC:803
GenBank: BC028297
Swiss-Prot: Q13733
Accession Number: NM_144699
Old Name: ATPase, Na+/K+ transporting, alpha polypeptide-like 2
PubMed (1981991): Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC. A detailed multipoint gene map of chromosome 1q.Genomics. 1990 Sep;8(1):13-21. Erratum in: Genomics 1991 Mar;9(3):564. PMID: 1981991 [PubMed - indexed for MEDLINE]

Utilizing genotyping data for 23 markers, we have constructed a 21-locus multipoint genetic map of the long arm of chromosome 1. Five new RFLPs are reported. The map integrates anonymous loci from previous primary linkage maps and incorporates markers for 10 coding sequences. These markers form a continuous linkage group of 85 cM in males and 141 cM in females. The map was constructed employing the LINKAGE and CRIMAP computational methodologies via a stepwise algorithm.

PubMed (3035563): Shull MM, Lingrel JB. Multiple genes encode the human Na+,K+-ATPase catalytic subunit.Proc Natl Acad Sci U S A. 1987 Jun;84(12):4039-43. PMID: 3035563 [PubMed - indexed for MEDLINE]

A human genomic library was constructed and screened with hybridization probes derived from sheep and rat cDNAs encoding the alpha and alpha(+) isoforms, respectively, of the Na+,K+-ATPase catalytic subunit. Genomic sequences spanning 150 kilobases were isolated. Four genes, designated alpha A, alpha B, alpha C, and alpha D, each 20-25 kilobases in length, were identified by restriction mapping, Southern blot hybridization analysis, and limited DNA sequencing. We present evidence that two of these genes, alpha A and alpha B, encode the alpha and alpha(+) isoforms, respectively. The other genes, alpha C and alpha D, one of which is physically linked to the alpha(+) gene, exhibit nucleotide and amino acid homology to Na+,K+-ATPase catalytic subunit cDNA sequences but do not correspond to any previously identified isoforms.