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Transporter Information:
Name: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1
Symbol: ATP6V0D1
TC: 3.A.2.2.3
Locations: 16
Aliases: ATP6DV, VATX, VPATPD, P39, Vma6
GenBank: X71490
Swiss-Prot: P12953
Accession Number: NM_004691
Old Name: ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D
PubMed (8250920): van Hille B, Vanek M, Richener H, Green JR, Bilbe G. Cloning and tissue distribution of subunits C, D, and E of the human vacuolarH(+)-ATPase.Biochem Biophys Res Commun. 1993 Nov 30;197(1):15-21. PMID: 8250920 [PubMed - indexed for MEDLINE]

The vacuolar proton ATPase (V-ATPase) translocates protons into intracellular organelles or across the plasma membrane of specialised cells such as osteoclast and renal intercalated cells. The catalytic site of the V-ATPase consists of a hexamer of three A subunits and three B subunits which bind and hydrolyse ATP and are regulated by accessory subunits C, D and E. cDNAs encoding subunits C, D, and E were cloned from human osteoclastoma, a tissue highly enriched in osteoclasts, as a first step in the characterisation of the V-ATPase used by the osteoclast. By Northern blot analysis only one mRNA species were detected for each of these subunits, which is consistent the constant transcription level in all tissues irrespective of the presence of specialised cells highly enriched in V-ATPases.