| Transporter Information: | |
| Name: | calcium channel, voltage-dependent, beta 3 subunit |
|---|---|
| Symbol: | CACNB3 |
| Locations: | 12q13 |
| Swiss-Prot: | P54284 |
| Accession Number: | NM_000725 |
| GDB | GDB:341023 |
| LocusLink | 784 |
| OMIM | 601958 |
| PubMed (8119293): | Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J. Cloning, chromosomal location and functional expression of the humanvoltage-dependent calcium-channel beta 3 subunit.Eur J Biochem. 1994 Feb 15;220(1):257-62. PMID: 8119293 [PubMed - indexed for MEDLINE] A novel human-voltage-dependent-calcium-channel (VDCC) beta subunit was isolated from a 9-week-old human total-embryo cDNA library. Of the four genes encoding beta-subunit isoforms that have been identified in animal species, this isoform shares strong similarity with the rat and rabbit beta 3-related gene product and is referred to here as H beta 3 subunit. The H beta 3 isoform is the second beta subunit identified in human. Its open reading frame encodes a 482-amino-acid protein with a predicted molecular mass of 54.571 kDa. The H beta 3 mRNA is expressed mostly in brain, smooth muscle and ovary. The gene for the human H beta 3 was specifically localized on chromosome 12q13. The cloned H beta 3 subunit was further expressed in Xenopus oocytes to demonstrate its ability to modulate VDCC activity. |
>P54284|CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3 - Homo sapiens (Human). MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPV QGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQ KQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMM AYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSL MPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP KDSY | |