TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | potassium voltage-gated channel, shaker-related subfamily, member 3 |
|---|---|
| Symbol: | KCNA3 |
| TC: | 1.A.1.2.2 |
| Locations: | 1p13.3 or 13 |
| Aliases: | MK3, HLK3, HPCN3, KV1.3 |
| GenBank: | L23499 |
| Swiss-Prot: | P22001 |
| Accession Number: | NM_002232 |
| GDB | GDB:128079 |
| LocusLink | 3738 |
| OMIM | 176263 |
| PubMed (2251283): | Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, ChandyKG. Expression and chromosomal localization of a lymphocyte K+ channel gene.Proc Natl Acad Sci U S A. 1990 Dec;87(23):9411-5. PMID: 2251283 [PubMed - indexed for MEDLINE] We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively. |
>sp|P22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3) - Homo sapiens (Human).
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGG
GGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAIL
YYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSK
ATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGL
LIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNN
NPNSCVNIKKIFTDV
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