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Transporter Information:
Name: potassium voltage-gated channel, subfamily G, member 3
Symbol: KCNG3
TC: 1.A.1.2.1
Locations: 2
Aliases: KV6.3, KV10.1
GenBank: AB070604
Swiss-Prot: Q8TAE7
Accession Number: NM_172344
PubMed (11852086): Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K,Matsushime H, Furuichi K. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit forvoltage-gated K(+) channel Kv2.1.FEBS Lett. 2002 Feb 13;512(1-3):230-4. PMID: 11852086 [PubMed - indexed for MEDLINE]

We report identification and characterization of Kv6.3, a novel member of the voltage-gated K(+) channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indicated that homomultimeric Kv6.3 did not yield a functional voltage-gated ion channel. When Kv6.3 and Kv2.1 were co-expressed, the heteromultimeric channels displayed the decreased rate of deactivation compared to the homomultimeric Kv2.1 channels. Immunoprecipitation studies indicated that Kv6.3 bound with Kv2.1 in co-transfected cells. These results indicate that Kv6.3 is a novel member of the voltage-gated K(+) channel which functions as a modulatory subunit.