| Transporter Information: | |
| Name: | potassium inwardly-rectifying channel, subfamily J, member 16 |
|---|---|
| Symbol: | KCNJ16 |
| TC: | 1.A.2.1.2 |
| Locations: | 17q23.1-q24.2 |
| Aliases: | Kir5.1 |
| Swiss-Prot: | Q9NPI9 |
| Accession Number: | NM_018658 |
| GDB | GDB:9838005 |
| LocusLink | 3773 |
| OMIM | 605722 |
| PubMed (11240146): | Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Muller R, Rajan S,Engel H, Grzeschik K, Daut J, Karschin A. Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.FEBS Lett. 2001 Mar 2;491(3):305-11. PMID: 11240146 [PubMed - indexed for MEDLINE] We have identified several cDNAs for the human Kir5.1 subunit of inwardly rectifying K(+) channels. Alternative splicing of exon 3 and the usage of two alternative polyadenylation sites contribute to cDNA diversity. The hKir5.1 gene KCNJ16 is assigned to chromosomal region 17q23.1-24.2, and is separated by only 34 kb from the hKir2.1 gene (KCNJ2). In the brain, Kir5.1 mRNA is restricted to the evolutionary older parts of the hindbrain, midbrain and diencephalon and overlaps with Kir2.1 in the superior/inferior colliculus and the pontine region. In the kidney Kir5.1 and Kir2.1 are colocalized in the proximal tubule. When expressed in Xenopus oocytes, Kir5.1 is efficiently targeted to the cell surface and forms electrically silent channels together with Kir2.1, thus negatively controlling Kir2.1 channel activity in native cells. |
>sp|Q9NPI9|IRK16_HUMAN Inward rectifier potassium channel 16 OS=Homo sapiens GN=KCNJ16 PE=2 SV=1 MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLS YILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCII NTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKL VNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKY YKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRET PYQKALLTLNRISVESQM | |