TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | potassium inwardly-rectifying channel, subfamily J, member 4 |
|---|---|
| Symbol: | KCNJ4 |
| TC: | 1.A.2.1.2 |
| Locations: | 22q13.1 |
| Aliases: | HIR, HRK1, HIRK2, Kir2.3 |
| Swiss-Prot: | P48050 |
| Accession Number: | NM_004981 |
| GDB | GDB:374080 |
| LocusLink | 3761 |
| OMIM | 600504 |
| PubMed (8016146): | Perier F, Radeke CM, Vandenberg CA. Primary structure and characterization of a small-conductance inwardlyrectifying potassium channel from human hippocampus.Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6240-4. PMID: 8016146 [PubMed - indexed for MEDLINE] We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics. Single-channel recordings indicate that the HIR channel has an unusually small conductance (13 pS), distinguishing HIR from other cloned inward rectifiers. RNA blot analyses show that HIR transcripts are present in heart, skeletal muscle, and several different brain regions, including the hippocampus. |
>sp|P48050|KCNJ4_HUMAN Inward rectifier potassium channel 4 OS=Homo sapiens OX=9606 GN=KCNJ4 PE=1 SV=1 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCI AFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVG CVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEP VVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAG LGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI | |