TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | potassium inwardly-rectifying channel, subfamily J, member 8 |
|---|---|
| Symbol: | KCNJ8 |
| TC: | 1.A.2.1.2 |
| Locations: | 12p11.23 |
| Aliases: | Kir6.1 |
| Swiss-Prot: | Q15842 |
| Accession Number: | NM_004982 |
| GDB | GDB:633096 |
| LocusLink | 3764 |
| OMIM | 600935 |
| PubMed (8595887): | Inagaki N, Inazawa J, Seino S. cDNA sequence, gene structure, and chromosomal localization of the humanATP-sensitive potassium channel, uKATP-1, gene (KCNJ8).Genomics. 1995 Nov 1;30(1):102-4. PMID: 8595887 [PubMed - indexed for MEDLINE] ATP-sensitive K+ (KATP) channels play a crucial role in coupling metabolic energy to the membrane potential of cells. Recently, we have isolated a KATP channel cDNA (uKATP-1) that is expressed ubiquitously in rat tissues including pancreatic islets, pituitary, skeletal muscle, and heart. Here, we report cloning of the human cDNA and gene encoding uKATP-1. Human uKATP-1 is a protein of 424 amino acids exhibiting 98% identity with rat uKATP-1. The human gene encoding uKATP-1, designated KCNJ8, is approximately 9.7 kb in length and is composed of three exons. KCNJ8 was mapped to chromosome 12p11.23 using fluorescence in situ hybridization. |
>sp|Q15842|IRK8_HUMAN ATP-sensitive inward rectifier potassium channel 8 OS=Homo sapiens GN=KCNJ8 PE=1 SV=1 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSF LCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLI LQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQW GHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRR NNSSLMVPKVQFMTPEGNQNTSES | |