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Transporter Information:
Name: sodium channel, voltage-gated, type X, alpha
Symbol: SCN10A
TC: 1.A.1.10.1
Locations: 3p21-p22
Aliases: hPN3
Swiss-Prot: Q9Y5Y9
Accession Number: NM_006514
Old Name: sodium channel, voltage-gated, type X, alpha polypeptide
PubMed (9839820): Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, Eglen RM,Hunter JC, Sangameswaran L. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal rootganglia, hPN3/SCN10A.Pain. 1998 Nov;78(2):107-14. PMID: 9839820 [PubMed - indexed for MEDLINE]

Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human sodium channel (hPN3, SCN10A) has been cloned from the lumbar 4/5 dorsal root ganglia (DRG). Expression of hPN3 in Xenopus oocytes showed that this clone is a functional voltage-gated sodium channel. The amino acid sequence of hPN3 is most closely related to the rat PN3/SNS sodium channels which are expressed primarily in the small neurons of rat DRGs. The homologous relationship between rPN3 and hPN3 is defined by (i) a high level of sequence identity (ii) sodium currents that are highly resistant to tetrodotoxin (TTX) (iii) similar tissue distribution profiles and (iv) orthologous chromosomal map positions. Since rPN3/SNS has been implicated in nociceptive transmission, hPN3 may prove to be a valuable target for therapeutic agents against neuropathic pain.