TRANSPORTERS FROM HUMANS:
| Transporter Information: | |
| Name: | solute carrier family 35 (UDP-galactose transporter), member A2 |
|---|---|
| Symbol: | SLC35A2 |
| TC: | 2.A.7.15.1 |
| Locations: | Xp11.23-p11.22 |
| Aliases: | UGAT, UGT |
| Swiss-Prot: | P78381 |
| Accession Number: | NM_005660 |
| Old Name: | solute carrier family 35 (UDP-galactose transporter), member 2 |
| GDB | GDB:454871 |
| LocusLink | 7355 |
| OMIM | 314375 |
| PubMed (8128316): | Hara T, Yamauchi M, Takahashi E, Hoshino M, Aoki K, Ayusawa D, Kawakita M. The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containingthe Wiskott-Aldrich syndrome locus.Somat Cell Mol Genet. 1993 Nov;19(6):571-5. PMID: 8128316 [PubMed - indexed for MEDLINE] We have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescent in situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS). |
>P78381|S35A2_HUMAN UDP-galactose translocator - Homo sapiens (Human).
MAAVGAGGSTAAPGPGAVSAGALEPGTASAAHRRLKYISLAVLVVQNASLILSIRYARTLPGDRFFATTAVVMAEVLKGL
TCLLLLFAQKRGNVKHLVLFLHEAVLVQYVDTLKLAVPSLIYTLQNNLQYVAISNLPAATFQVTYQLKILTTALFSVLML
NRSLSRLQWASLLLLFTGVAIVQAQQAGGGGPRPLDQNPGAGLAAVVASCLSSGFAGVYFEKILKGSSGSVWLRNLQLGL
FGTALGLVGLWWAEGTAVATRGFFFGYTPAVWGVVLNQAFGGLLVAVVVKYADNILKGFATSLSIVLSTVASIRLFGFHV
DPLFALGAGLVIGAVYLYSLPRGAAKAIASASASASGPCVHQQPPGQPPPPQLSSHRGDLITEPFLPKLLTKVKGS
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