TCDB is operated by the Saier Lab Bioinformatics Group
Transporter Information:
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
Symbol: SLC7A3
TC: 2.A.3.3.1
Locations: Xq12
Aliases: CAT-3, ATRC3, FLJ14541
GenBank: AF320612
Swiss-Prot: Q8N185
Accession Number: NM_032803
PubMed (11591158): Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI. Human cationic amino acid transporter hCAT-3 is preferentially expressed inperipheral tissues.Biochemistry. 2001 Oct 16;40(41):12387-94. PMID: 11591158 [PubMed - indexed for MEDLINE]

At least five distinct carrier proteins form the family of mammalian cationic amino acid transporters (CATs). We have cloned a cDNA containing the complete coding region of human CAT-3. hCAT-3 is glycosylated and localized to the plasma membrane. Transport studies in Xenopus laevis oocytes revealed that hCAT-3 is selective for cationic L-amino acids and exhibits a maximal transport activity similar to other CAT proteins. The apparent substrate affinity and sensitivity to trans-stimulation of hCAT-3 resembles most closely hCAT-2B. This is in contrast to rat and murine CAT-3 proteins that have been reported to display a very low activity and to be inhibited by neutral and anionic L-amino acids as well as D-arginine (Hosokawa, H., et al. (1997) J. Biol. Chem. 272, 8717-8722; Ito, K., and Groudine, M. (1997) J. Biol. Chem. 272, 26780-26786). Also, in adult rat and mouse, CAT-3 has been found exclusively in central neurons. Human CAT-3 expression is not restricted to the brain, in fact, by far the highest expression was found in thymus. Also in other peripheral tissues, hCAT-3 expression was equal to or higher than in most brain regions, suggesting that hCAT-3 is not a neuron-specific transporter.