TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.23.1.1
Type VI secretion system (T6SS) VasA-L + Vca0107-09; + Vca0123 + Vc1416 (Pukatzki et al., 2006; Pukatzki et al., 2007). This secretion system displays antimicrobial properties (Macintyre et al., 2010).  It functions like contractile tails of phage and penetrates cells with a trimeric VgrG spike protein to which are associated PAAR repeat proteins that sharpen the tip of the spike and are released into the cytoplasm of the target cell (Shneider et al. 2013). Certain Vibrionaceae adapted their antibacterial T6SS to mediate interactions with eukaryotic hosts or predators, promoting their toxicity (Dar et al. 2018).

Accession Number:B2D7K2
Protein Name:VgrG-3
Length:1017
Molecular Weight:112972.00
Species:Vibrio cholerae MZO-3 GN=vgrG-3 PE=4 SV=1 [412883]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate protein polypeptide chain, deoxyribonucleic acid

Cross database links:

Pfam: PF01471   

Gene Ontology

GO:0008152 P:metabolic process

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MARLQFQLKV DGLEDESLVV RGFEGQESLS DSVWRSEPCY GFRYQVDLAS ALSNLVAEQF 
61:	VDQTAHLTIL RDGQAVQQIN GIVRQFSKGD TGRRHTFYSL TLVPALERLS LRSNSRIFQQ 
121:	QSVPEIISIL LQEMGIEDYA FALKRECAQR EFCVQYRETD LQFLHRIAAE EGLVYSHLHE 
181:	AQKHTLLFTD SSDSQPKLAK PVPYNALAGG EINLPYVVDL QFKTIAQVSH TELKDYSFKK 
241:	PAYGFTQRTQ GKDIAYQQPN YEHFDAPGRY KDDANGKAFS QIRLEYLRRD ALLADAKSDE 
301:	PLLLAGVRFD LQDHLDLAMN RDWLVVQANH QGTQPQALQE EGGSGATTYS NQLKLIPAHI 
361:	TWRARPCAKP QVDGPMIATV VGPQGEEIYC DNFGRVKVHF PWDRYSSSNE KSSCWVRVAQ 
421:	EWAGSQYGSM AIPRVGHEVI VSFLNGDPDQ PIITGRTYHA TNTAPYALPD HKTKTVLRTE 
481:	THQGQGYNEL SFEDQAGSEQ ILLHAQKDWD ALIEHDHTEV IRHDQHLTVD NDRFIRIQRN 
541:	QHVTIEGESR SKIALDSSHE VGASLQHKVG QRIAVEAGKE ISLKSGAKIV VEAGAELTLK 
601:	AGGSFVKVDA GGVHLVGPAI NLNAGGSAGS GSAYGGQLAA APRMLAQAKP VAELVQPDIA 
661:	ASMQSGAARV IDVASLPTMM PSSANNTAND EPVAEEKTPE RILKSDLLKP SDELEKLAKR 
721:	QASAYRQGNH SDEVKLLQEA LIKLGFDLGK AGADGDFGGK TKTAIEQFQK SYQPSHQTHP 
781:	SYSIGPVDGI VGNGTLLALD EALMDGWVYE NNIYQIWPLG KTSEKYESAG RGPGVISTGN 
841:	GDYGGASYGC YQMSSNLGVV QKYIQSSKFK EFFSGLNPAT KEFNVVWQDI ASRYPQEFRE 
901:	EQHQFIKRTH YDIQIGHLRG KGLLFEHNRA AVHDLIWSTS VQFGGRTNLI FNALNGQNME 
961:	SMTDKDIIIL VQDYKLVNTE RLFKSSPSWW SDLKKRAVSE KKALLELEID GLEVDIK