4.A.3.2.10
Oligo β-(gluco)mannoside (derived from (gluco)mannan))-specific PTS transporter, GmuABC (YdhNMO). The glucomannan utilization operon (gmuBACDREFG, formerly ydhMNOPQRST) of Bacillus subtilis has been characterized (Sadaie et al. 2008).
Transcription of the operon is induced by konjac glucomannan and
requires the last mannanase gene (gmuG). Cellobiose and mannobiose,
possible degradation products of glucomannan by GmuG, are strong
inducers of transcription. An internal regulatory gene
(gmuR) encodes a repressor of the operon, as disruption of this gene
enhances transcription of the operon in the absence of inducers. The
expression of the glucomannan utilizing operon is thus induced by degraded glucomannan products, and repressed by an internal repressor (Sadaie et al. 2008).
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| Accession Number: | O05507 |
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| Protein Name: | PTS system oligo-beta-mannoside-specific EIIC component |
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| Length: | 442 |
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| Molecular Weight: | 48436.00 |
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| Species: | Bacillus subtilis (strain 168) [224308] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
glucan, glucooligosaccharide, cellobiose |
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1: MFEKISQFLV PIAGRLNNNR YLQVLRDAFM LAFPLTIFGS IFVVLTNLPF LNKIMNASML
61: TSFQSHFGIA STATMGIMSV FVVFGIGYYL SKSYQVEAVF GGAIALVSFL LLTPFIIQPE
121: TGDAITGVIP VDRLGAKGMF LGMITAFLSG EIYRRIVQKN LTIKMPAGVP PAVAKSFAAL
181: IPAFITLTVF LLINVMVTLF FKTNMHDVIY HAIQAPLVGL GSGIIPTLIA VFFIQILWFF
241: GLHGQIIINS VMDPIWNTLQ VENLSAYTAG KEIPHIISKP FMEIYTVGMG GTGMTLAIVF
301: TILIFMKSRQ MKQVSKLGLA PGIFNVNEPI IFGLPIVMNP IIIVPWVLAP MVVTLVTYLA
361: MSAGLVPPPT GVTVPWTVPL FINGIMATNS IMGGVMQLIN LLIVFVIWFP FLKAMDKLNL
421: AKEKEQAVQE TAAQQNDNSI KM