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9.A.3.1.1
The PDZ domain-containing SNX27-retromer assembly apparatus together with the retromer subunit, ANKRD50 (Kvainickas et al. 2016). Retromer subunits include VPS26A/B (327 and 336 aas, respectively) (also cargo binding proteins) VPS35 (MEM3; 796 aas) and VPS29 (DC7, DC15; 182 aas).  SNX3 (162 aas) and Rab7A (207 aas) mediate recruitment to endosomes, but SNX3 is also a cargo adaptor (McNally and Cullen 2018). Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation (Del Puerto et al. 2021).

Accession Number:O75436
Protein Name:Vacuolar protein sorting-associated protein 26A
Length:327
Molecular Weight:38170.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

Cross database links:

Structure:
2FAU   5F0J   5F0L   5F0M   5F0P     

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FASTA formatted sequence
1:	MSFLGGFFGP ICEIDIVLND GETRKMAEMK TEDGKVEKHY LFYDGESVSG KVNLAFKQPG 
61:	KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRSYDFE FMQVEKPYES 
121:	YIGANVRLRY FLKVTIVRRL TDLVKEYDLI VHQLATYPDV NNSIKMEVGI EDCLHIEFEY 
181:	NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP 
241:	VKGESIPIRL FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE 
301:	KLRKQRTNFH QRFESPESQA SAEQPEM