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1.A.30.2.2
The TolA energy-transducing system. TolQ/R (the putative H+ channel) are listed here; TolA is listed under TC# 2.C.1.2.1, together with its auxiliary proteins. The channel is lined by TolR-Asp23, TolQ-Thr145 and TolQ-Thr178.  The Tol-Pal complex, energized by TolQRA, and using the outer membrane proteins, BtuB and OmpF as receptors, is responsible for the uptake of colicin ColE9 and other bacteriocins; in this process, the complex in the outer membrane bridges and immobilizes the complex components in the inner membrane (Rassam et al. 2018).

Accession Number:P0ABU9
Protein Name:Protein TolQ aka FII aka B0737
Length:230
Molecular Weight:25598.00
Species:Escherichia coli [83333]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

RefSeq: AP_001375.1    NP_415265.1   
Entrez Gene ID: 948900   
Pfam: PF01618   
BioCyc: EcoCyc:EG11010-MONOMER    ECOL168927:B0737-MONOMER   
KEGG: ecj:JW0727    eco:b0737   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0008565 F:protein transporter activity
GO:0043213 P:bacteriocin transport
GO:0017038 P:protein import

References (8)

[1] “Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli.”  Sun T.-P.et.al.   3294803
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Membrane topology of the Escherichia coli TolR protein required for cell envelope integrity.”  Muller M.M.et.al.   8376353
[6] “Membrane topologies of the TolQ and TolR proteins of Escherichia coli: inactivation of TolQ by a missense mutation in the proposed first transmembrane segment.”  Kampfenkel K.et.al.   8331075
[7] “Membrane topology and mutational analysis of the TolQ protein of Escherichia coli required for the uptake of macromolecules and cell envelope integrity.”  Vianney A.et.al.   8300535
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTDMNILDLF LKASLLVKLI MLILIGFSIA SWAIIIQRTR ILNAAAREAE AFEDKFWSGI 
61:	ELSRLYQESQ GKRDNLTGSE QIFYSGFKEF VRLHRANSHA PEAVVEGASR AMRISMNREL 
121:	ENLETHIPFL GTVGSISPYI GLFGTVWGIM HAFIALGAVK QATLQMVAPG IAEALIATAI 
181:	GLFAAIPAVM AYNRLNQRVN KLELNYDNFM EEFTAILHRQ AFTVSESNKG