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1.A.11.4.3
Rhesus (Rh) complex (tetramer: RhAG2, RhCE1, RhD1) of 409 aas and 12 TMSs. Exports ammonia from human red blood cells (Conroy et al., 2005). RhAG is also called RH50.  RhAG variants (I61R, F65S), associated with overhydrated hereditary stomatocytosis (OHSt), a disease affecting erythrocytes, are alterred for bidirectional ammonium transport (Deschuyteneer et al. 2013).  The system transports ammonia, methylammonia, ethylammonia, fluoroethylamine and CO2 Michenkova et al. 2021.  19F-fluoroethylamine has been used to study rapid transport as its NMR spectra are different inside and outside of human red blook cells (Szekely et al. 2006).

Accession Number:P18577
Protein Name:Blood group Rh(CE) polypeptide aka RhCE
Length:417
Molecular Weight:45560.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ammonium, methylamine, ethylamine, carbon dioxide

Cross database links:

RefSeq: NP_065231.2    NP_619522.2    NP_619523.2    NP_619524.2   
Entrez Gene ID: 6006   
Pfam: PF00909   
OMIM: 111690  phenotype
111700  gene+phenotype
KEGG: hsa:6006   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0008519 F:ammonium transmembrane transporter activity
GO:0055085 P:transmembrane transport

References (17)

[1] “cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression.”  Avent N.D.et.al.   2123099
[2] “Molecular cloning and protein structure of a human blood group Rh polypeptide.”  Cherif-Zahar B.et.al.   1696722
[3] “Multiple Rh messenger RNA isoforms are produced by alternative splicing.”  le van Kim C.et.al.   1379850
[4] “Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.”  Kajii E.et.al.   7916743
[5] “16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype.”  Westhoff C.M.et.al.   11380456
[6] “E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.”  Kashiwase K.et.al.   11724987
[7] “Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.”  Noizat-Pirenne F.et.al.   12393640
[8] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.”  Cherif-Zahar B.et.al.   8188244
[11] “Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.”  Avent N.D.et.al.   3146980
[12] “Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.”  Bloy C.et.al.   3135863
[13] “Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells.”  Kajii E.et.al.   7789951
[14] “Identification of two Rh mRNA isoforms expressed in immature erythroblasts.”  Umenishi F.et.al.   8117271
[15] “Regarding the size of Rh proteins.”  Suyama K.et.al.   1898705
[16] “RHCE represents the ancestral RH position, while RHD is the duplicated gene.”  Wagner F.F.et.al.   11902138
[17] “Molecular genetic basis of the human Rhesus blood group system.”  Mouro I.et.al.   8220426

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FASTA formatted sequence 
1:	MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAL 
61:	GLGFLTSNFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPPGKVVITL FSIRLATMSA 
121:	MSVLISAGAV LGKVNLAQLV VMVLVEVTAL GTLRMVISNI FNTDYHMNLR HFYVFAAYFG 
181:	LTVAWCLPKP LPKGTEDNDQ RATIPSLSAM LGALFLWMFW PSVNSPLLRS PIQRKNAMFN 
241:	TYYALAVSVV TAISGSSLAH PQRKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
301:	AGLISIGGAK CLPVCCNRVL GIHHISVMHS IFSLLGLLGE ITYIVLLVLH TVWNGNGMIG 
361:	FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHVAK YFDDQVFWKF PHLAVGF