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4.A.2.1.10
The FrwABCD putative transporter of unknown function. FruA is a 3-domain multiphosphoryl transfer protein: EIAni-HPr-IIAFru (Reizer et al., 1995).

Accession Number:P32672
Protein Name:Fructose-like permease IIC component 2
Length:359
Molecular Weight:37086.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: AP_003861.1    NP_418384.1   
Entrez Gene ID: 948448   
BioCyc: EcoCyc:FRWC-MONOMER    ECOL168927:B3949-MONOMER   
KEGG: ecj:JW3921    eco:b3949   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (5)

[1] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Novel phosphotransferase system genes revealed by bacterial genome analysis -- a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system.”  Reizer J.et.al.   7773398
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MNELVQILKN TRQHLMTGVS HMIPFVVSGG ILLAVSVMLY GKGAVPDAVA DPNLKKLFDI 
61:	GVAGLTLMVP FLAAYIGYSI AERSALAPCA IGAWVGNSFG AGFFGALIAG IIGGIVVHYL 
121:	KKIPVHKVLR SVMPIFIIPI VGTLITAGIM MWGLGEPVGA LTNSLTQWLQ GMQQGSIVML 
181:	AVIMGLMLAF DMGGPVNKVA YAFMLICVAQ GVYTVVAIAA VGICIPPLGM GLATLIGRKN 
241:	FSAEERETGK AALVMGCVGV TEGAIPFAAA DPLRVIPSIM VGSVCGAVTA ALVGAQCYAG 
301:	WGGLIVLPVV EGKLGYIAAV AVGAVVTAVC VNVLKSLARK NGSSTDEKED DLDLDFEIN