Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.34.1.1
The Bacillus SpoIIQ/SpoIIIAH transcompartment channel interconnects the forespore and the mother cell. The activity of sigmaG requires this channel apparatus through which the adjacent mother cell provides substrates that generally support gene expression in the forespore. Flanagan et al. 2016 reported that SpoIIQ is bifunctional, specifically maximizing sigmaG activity as part of a regulatory circuit that prevents sigmaG from activating transcription of the gene encoding its own inhibitor, the anti-sigma factor CsfB.

Accession Number:P49785
Protein Name:Stage III sporulation protein AH
Length:218
Molecular Weight:23806.00
Species:Bacillus subtilis [1423]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 938600   
Pfam: PF12685   
KEGG: bsu:BSU24360   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0030435 P:sporulation resulting in formation of a cellular spore

References (11)

[1] “Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes.”  Mizuno M.et.al.   8969508
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[4] “Zipper-like interaction between proteins in adjacent daughter cells mediates protein localization.”  Blaylock B.et.al.   15574594
[5] “Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.”  Doan T.et.al.   15752199
[6] “Engulfment-regulated proteolysis of SpoIIQ: evidence that dual checkpoints control sigma activity.”  Jiang X.et.al.   16164552
[7] “Forespore engulfment mediated by a ratchet-like mechanism.”  Broder D.H.et.al.   16959571
[8] “Dual localization pathways for the engulfment proteins during Bacillus subtilis sporulation.”  Aung S.et.al.   17824930
[9] “SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis.”  Campo N.et.al.   18077456
[10] “A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.”  Camp A.H.et.al.   18485064
[11] “A channel connecting the mother cell and forespore during bacterial endospore formation.”  Meisner J.et.al.   18812514
Structure:
3TUF   3UZ0     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLKKQTVWLL TMLSLVVVLS VYYIMSPESK NAVQMQSEKS ASDSGEVATE KAPAKQDTKE 
61:	KSGTETEKGK EDGTKGTKDS SADKETSAEA SEKGTVVTET ADDDLFTTYR LDLEDARSKE 
121:	REELNAIVSS DDATAKEKSE AYDKMTALSE VEGTEKQLET LIKTQGYEDA LVNAEGDKIN 
181:	ITVKSDKHSK SKATAIIDLV AKEIKTMKDV AVTFEPSK