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2.A.7.1.5
The heterooligomeric drug resistance efflux pump, YkkCD (substrates: ethidium bromide, proflavin, tetraphenylarsonium chloride, crystal violet, pyronin Y, methylviologen, cetylperdinium chloride, streptomycin, tetracycline, chloramphenicol, phosphonomycin)

Accession Number:P49857
Protein Name:YkkD
Length:105
Molecular Weight:11325.00
Species:Bacillus subtilis [1423]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate crystal violet, fosfomycin, chloramphenicol, tetracycline, streptomycin, 3,6-diaminoacridine, pyronin Y, ethidium bromide

Cross database links:

RefSeq: NP_389193.1   
Entrez Gene ID: 938109   
Pfam: PF00893   
KEGG: bsu:BSU13100   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0006810 P:transport

References (3)

[1] “Oxygen-controlled regulation of the flavohemoglobin gene in Bacillus subtilis.”  Lacelle M.et.al.   8682784
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins.”  Jack D.L.et.al.   10735877

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLHWISLLCA GCLEMAGVAL MNQYAKEKSV KWVLLIIVGF AASFSLLSYA METTPMGTAY 
61:	AVWTGIGTAG GALIGILFYK EQKDAKRIFF IALILCSAVG LKILS