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3.A.11.2.1
The single stranded DNA uptake competence transporter, ComEA/ComEC (Rec2)

Accession Number:P51973
Protein Name:ComEC aka ComA
Length:691
Molecular Weight:74358.00
Species:Neisseria gonorrhoeae [485]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate DNA

Cross database links:

Pfam: PF03772   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016787 F:hydrolase activity
GO:0030420 P:establishment of competence for transformation
GO:0006810 P:transport

References (2)

[1] “A novel determinant (comA) essential for natural transformation competence in Neisseria gonorrhoeae and the effect of a comA defect on pilin variation.”  Facius D.et.al.   7934834
[2] “A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural transformation competence of Neisseria gonorrhoeae.”  Fussenegger M.et.al.   8830266

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MLCVLAGAAY GVFRTEAALS SQWRAEAVSG VPLTVEVTDM PRSDGRRVQF AAKAVDSGGR 
61:	TFDLLLSDYK RREWAVGSRW RITARVHPVV GELNLRGLNR EAWALSNGVG GVGTVGADRV 
121:	LLHGGSGWGI AVWRSRISRN WRQADADGGL SDGIGLMRAL SVGEQSALRP GLWQAFRPLG 
181:	LTHLVSISGL HVTMVAVLFA WLAKRLLACS PRLPARPRAW VLAAGCAGAL FYALLAGFSV 
241:	PTQRSVLMLA AFAWAWRRGR LSAWATWWQA LAAVLLFDPL AVLGVGTWLS FGLVAALIWA 
301:	CAGRLYEGKR QTAVRGQWAA SVLSLVLLGY LFASLPLVSP LVNAVSIPWF SWVLTPLALL 
361:	GSVVPFAPLQ QAGAFLAEYT LRFLVWLADV SPEFAVAAAP LPLLVLAVCA ALLLLLPRGL 
421:	GLRPWAVLLL AGFVSYRPEA VPENEAAVTV WDAGQGLSVL VRTANRHLLF DTGTVAAAQT 
481:	GIVPSLNAAG VRRLDKLVLS HHDSDHDGGF QAVGKIPNGG IYAGQPEFYE GARHCAEQRW 
541:	QWDGVDFEFL RPSERKNIDD NGKSCVLRVV AGGAALLVTG DLDTKGEESL VGKYGGNLYS 
601:	QVLVLGHHGS NTSSSGVFLN AVSPEYAVAS SGYANAYKHP TEAVQNRVRA HGIKLLRTDL 
661:	SGALQFGLGR GGVKAQRLRV YKFYWQKKPF E