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The U snRNA export complex including: phosphorylated adaptor for RNA export (PHAX/RNUXA), nuclear cap-binding protein-1/2 (NCBP1/NCBP2), and RAN GTPase (see also 9.A.50).

Accession Number:P52298
Protein Name:Nuclear cap-binding protein subunit 2
Molecular Weight:18001.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate small nuclear RNA

Cross database links:

DIP: DIP-33246N
Entrez Gene ID: 22916   
Pfam: PF00076   
KEGG: hsa:22916   

Gene Ontology

GO:0005829 C:cytosol
GO:0005845 C:mRNA cap binding complex
GO:0005654 C:nucleoplasm
GO:0000166 F:nucleotide binding
GO:0005515 F:protein binding
GO:0000340 F:RNA 7-methylguanosine cap binding
GO:0031047 P:gene silencing by RNA
GO:0008334 P:histone mRNA metabolic process
GO:0031124 P:mRNA 3'-end processing
GO:0006370 P:mRNA capping
GO:0006406 P:mRNA export from nucleus
GO:0034660 P:ncRNA metabolic process
GO:0000184 P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0046833 P:positive regulation of RNA export from nucleus
GO:0050434 P:positive regulation of viral transcription
GO:0006446 P:regulation of translational initiation
GO:0006408 P:snRNA export from nucleus
GO:0000387 P:spliceosomal snRNP assembly
GO:0006369 P:termination of RNA polymerase II transcription
GO:0006368 P:transcription elongation from RNA polymerase II promoter
GO:0016032 P:viral reproduction

References (20)

[1] “A cap-binding protein complex mediating U snRNA export.”  Izaurralde   7651522
[2] “Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein.”  Kataoka   7478990
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project   15489334
[5] “A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export.”  Visa   8601613
[6] “Interaction between the human nuclear cap-binding protein complex and hnRNP F.”  Gamberi   9111328
[7] “Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.”  Ishigaki   11551508
[8] “The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.”  Lejeune   12093754
[9] “eIF4G is required for the pioneer round of translation in mammalian cells.”  Lejeune   15361857
[10] “Human mRNA export machinery recruited to the 5' end of mRNA.”  Cheng   17190602
[11] “The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export.”  Nojima   17363367
[12] “Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.”  Matsuda   17873884
[13] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.”  Matsuoka   17525332
[14] “NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.”  Woeller   18369367
[15] “Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.”  Gruber   19632182
[16] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary   19608861
[17] “Initial characterization of the human central proteome.”  Burkard   21269460
[18] “Crystal structure of the human nuclear cap binding complex.”  Mazza   11545740
[19] “Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex.”  Mazza   12374755
[20] “Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.”  Calero   12434151
1H2T   1H2U   1H2V   1H6K   1N52   1N54   3FEX   3FEY   5OO6   5OOB   [...more]

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