| |
|---|---|
| Accession Number: | P62826 |
| Protein Name: | GTP-binding nuclear protein Ran |
| Length: | 216 |
| Molecular Weight: | 24423.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | small nuclear RNA |
Cross database links:
| DIP: | DIP-5929N |
|---|---|
| Entrez Gene ID: | 5901 |
| Pfam: | PF00071 |
| KEGG: | hsa:5901 |
Gene Ontology
GO:0005829
C:cytosol
GO:0042470
C:melanosome
GO:0005643
C:nuclear pore
GO:0005654
C:nucleoplasm
GO:0050681
F:androgen receptor binding
GO:0003682
F:chromatin binding
GO:0005525
F:GTP binding
GO:0003924
F:GTPase activity
GO:0003713
F:transcription coactivator activity
GO:0030521
P:androgen receptor signaling pathway
GO:0051301
P:cell division
GO:0006259
P:DNA metabolic process
GO:0007067
P:mitosis
GO:0007052
P:mitotic spindle organization
GO:0045893
P:positive regulation of transcription, DNA-dependent
GO:0006611
P:protein export from nucleus
GO:0006405
P:RNA export from nucleus
GO:0007264
P:small GTPase mediated signal transduction
GO:0046796
P:viral genome transport in host cell
GO:0019058
P:viral infectious cycle
| |
References (32)[1] “Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.” Drivas G.T.et.al. 2108320 [2] “Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.” Matsumoto T.et.al. 1855255 [3] “Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.” Ren M.et.al. 8421051 [4] “The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.” Hsiao P.-W.et.al. 10400640 [5] “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.” Zhang Q.-H.et.al. 11042152 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.” Bischoff F.R.et.al. 1961752 [8] “Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.” Moroianu J.et.al. 8692944 [9] “CRM1 is an export receptor for leucine-rich nuclear export signals.” Fornerod M.et.al. 9323133 [10] “The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.” Askjaer P.et.al. 9837918 [11] “CRM1-mediated recycling of snurportin 1 to the cytoplasm.” Paraskeva E.et.al. 10209022 [12] “RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.” Englmeier L.et.al. 11571268 [13] “Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.” Lindsay M.E.et.al. 11425870 [14] “Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.” Zou Y.et.al. 14500717 [15] “Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.” Haendeler J.et.al. 12808100 [16] “A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.” Hakata Y.et.al. 14612415 [17] “A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.” Wang D.et.al. 14684163 [18] “Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.” Petosa C.et.al. 15574331 [19] “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.” Rush J.et.al. 15592455 [20] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [21] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.” Rikova K.et.al. 18083107 [22] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.” Meierhofer D.et.al. 18781797 [23] “A survivin-ran complex regulates spindle formation in tumor cells.” Xia F.et.al. 18591255 [24] “Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.” Sanz-Garcia M.et.al. 18617507 [25] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [26] “An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.” Heibeck T.H.et.al. 19534553 [27] “The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.” Medendorp K.et.al. 19753112 [28] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 | |
| Structure: | |
| [...more] | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 61: FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 121: GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 181: ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL