TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.7.1.9
The spermidine exporter, MdtIJ (MdtIJ = YdgEF) (Higashi et al., 2008).  Catalyzes the export of spermidine and putrescine, and confers resistance to deoxycholate and SDS (Nishino and Yamaguchi 2001). It can be induced by these polyamines and bile salts. Details of the induction mechanism are known (Leuzzi et al. 2015).

Accession Number:P69213
Protein Name:MdtJ
Length:121
Molecular Weight:13115.00
Species:Escherichia coli O157:H7 [83334]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Spermidine, Deoxycholate, SDS

Cross database links:

RefSeq: NP_288035.1    NP_310333.1   
Entrez Gene ID: 913399    961548   
Pfam: PF00893   
BioCyc: ECOL83334:ECS2306-MONOMER   
KEGG: ece:Z2594    ecs:ECs2306   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015606 F:spermidine transmembrane transporter activity
GO:0015848 P:spermidine transport

References (2)

[1] “Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.”  Perna N.T.et.al.   11206551
[2] “Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.”  Hayashi T.et.al.   11258796

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MYIYWILLGL AIATEITGTL SMKWASVSEG NGGFILMLVM ISLSYIFLSF AVKKIALGVA 
61:	YALWEGIGIL FITLFSVLLF DESLSLMKIA GLTTLVAGIV LIKSGTRKAR KPELEVNHGA 
121:	V