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1.A.34.1.1
The Bacillus SpoIIQ/SpoIIIAH transcompartment channel interconnects the forespore and the mother cell. The activity of sigmaG requires this channel apparatus through which the adjacent mother cell provides substrates that generally support gene expression in the forespore. Flanagan et al. 2016 reported that SpoIIQ is bifunctional, specifically maximizing sigmaG activity as part of a regulatory circuit that prevents sigmaG from activating transcription of the gene encoding its own inhibitor, the anti-sigma factor CsfB.

Accession Number:P71044
Protein Name:Stage II sporulation protein Q
Length:283
Molecular Weight:31113.00
Species:Bacillus subtilis [1423]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Forespore membrane1 / Single-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_391536.1   
Entrez Gene ID: 936951   
Pfam: PF01551   
BioCyc: SUBTI:BSU36550-MONOMER   
KEGG: bsu:BSU36550   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0004222 F:metalloendopeptidase activity
GO:0006508 P:proteolysis
GO:0030435 P:sporulation resulting in formation of a cel...

References (14)

[1] “The Bacillus subtilis ureABC operon.”  Cruz-Ramos H.et.al.   9150240
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “SpoIIQ, a forespore-expressed gene required for engulfment in Bacillus subtilis.”  Londono-Vallejo J.A.et.al.   9140963
[4] “A dispensable role for forespore-specific gene expression in engulfment of the forespore during sporulation of Bacillus subtilis.”  Sun Y.-L.et.al.   10781563
[5] “Septal localization of forespore membrane proteins during engulfment in Bacillus subtilis.”  Rubio A.et.al.   15044948
[6] “Zipper-like interaction between proteins in adjacent daughter cells mediates protein localization.”  Blaylock B.et.al.   15574594
[7] “Developmental commitment in a bacterium.”  Dworkin J.et.al.   15882622
[8] “Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.”  Doan T.et.al.   15752199
[9] “Engulfment-regulated proteolysis of SpoIIQ: evidence that dual checkpoints control sigma activity.”  Jiang X.et.al.   16164552
[10] “Forespore engulfment mediated by a ratchet-like mechanism.”  Broder D.H.et.al.   16959571
[11] “Dual localization pathways for the engulfment proteins during Bacillus subtilis sporulation.”  Aung S.et.al.   17824930
[12] “SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis.”  Campo N.et.al.   18077456
[13] “A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.”  Camp A.H.et.al.   18485064
[14] “A channel connecting the mother cell and forespore during bacterial endospore formation.”  Meisner J.et.al.   18812514
Structure:
3TUF   3UZ0     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MREEEKKTSQ VKKLQQFFRK RWVFPAIYLV SAAVILTAVL WYQSVSNDEV KDQLADNGGN 
61:	SAYDNNDDAV EVGKSMENVA MPVVDSENVS VVKKFYETDA AKEEKEAALV TYNNTYSLSK 
121:	GIDLAEKDGK DFDVSASLSG TVVKAEKDPV LGYVVEVEHA DGLSTVYQSL SEVSVEQGDK 
181:	VKQNQVIGKS GKNLYSEDSG NHVHFEIRKD GVAMNPLNFM DKPVSSIEKA ATQETEESIQ 
241:	QSSEKKDGST EKGTEEKSGE KKDDSTDKSG SKESSTTEDT EQS