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2.A.7.22.1
4-amino-4-deoxy-L-arabinose phosphoundecaprenol flippase, ArnEF [ArnE, 111aas; 4 TMSs; PmrL; YfbW] [ArnF, 128aas; 4 TMSs; PmrM; YfbJ] Functions in modification of lipid A during biosynthesis of lipopolysaccharide. Required for resistance to polymyxin and cationic antimicrobial peptides (Yan et al., 2007).

Accession Number:P76474
Protein Name:Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF
Length:128
Molecular Weight:14085.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate polymyxin

Cross database links:

DIP: DIP-48225N
Entrez Gene ID: 945344   
KEGG: eco:b2258   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0022891 F:substrate-specific transmembrane transporter activity
GO:0009245 P:lipid A biosynthetic process
GO:0010041 P:response to iron(III) ion

References (6)

[1] “Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli.”  Sharma V.et.al.   8626063
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[5] “Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes.”  Winfield M.D.et.al.   15569938
[6] “An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli.”  Yan A.et.al.   17928292

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGLMWGLFSV IIASVAQLSL GFAASHLPPM THLWDFIAAL LAFGLDARIL LLGLLGYLLS 
61:	VFCWYKTLHK LALSKAYALL SMSYVLVWIA SMVLPGWEGT FSLKALLGVA CIMSGLMLIF 
121:	LPTTKQRY