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1.A.69.1.1
Heteromeric odorant receptor, OR (Sato et al., 2008). OR22a senses fruit-derived esters. These olfactory receptors may have 3-d structures resembling animal rhodopsins, human citronellic terpenoid receptors, OR1A1 and OA1A2 and the mouse eugenol receptor, OR-EG (Ramdya and Benton, 2010). Molecular modelling of oligomeric states of DmOR83b has been reported (Harini and Sowdhamini, 2012).  Recombinant receptor together with the co-receptor, Orco, has been overproduced, purified and reconstituted in a lipid bilayer (Carraher et al. 2013).  Orco (Or83b) forms a dimer that is fully functional for Ca2+ transport, is regulated by calmodulin and interacts normally with Or22a.  The native Orco is therefore probably a dimer (Mukunda et al. 2014). Fertility decline in female mosquitoes is regulated by the orco olfactory co-receptor (David et al. 2023).  OR46  is a potential sensory receptor associated with host detection in the livestock pest Lucilia cuprina (Wulff et al. 2024).

Accession Number:P81909
Protein Name:OR22a
Length:397
Molecular Weight:46754.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate inorganic cation, calcium(2+)

Cross database links:

DIP: DIP-20484N
RefSeq: NP_523453.1   
Entrez Gene ID: 33335   
Pfam: PF02949   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-006863-MONOMER   
KEGG: dme:Dmel_CG1219   

Gene Ontology

GO:0030425 C:dendrite
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005549 F:odorant binding
GO:0004984 F:olfactory receptor activity
GO:0005515 F:protein binding
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0050896 P:response to stimulus
GO:0007608 P:sensory perception of smell
GO:0007165 P:signal transduction

References (8)

[1] “Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.”  Gao Q.et.al.   10458908
[2] “Nucleotide and copy-number polymorphism at the odorant receptor genes Or22a and Or22b in Drosophila melanogaster.”  Aguade M.et.al.   18922763
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[5] “A spatial map of olfactory receptor expression in the Drosophila antenna.”  Vosshall L.B.et.al.   10089887
[6] “A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.”  Clyne P.J.et.al.   10069338
[7] “Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.”  Benton R.et.al.   16402857
[8] “Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.”  Wicher D.et.al.   18408711

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FASTA formatted sequence 
1:	MLSKFFPHIK EKPLSERVKS RDAFIYLDRV MWSFGWTEPE NKRWILPYKL WLAFVNIVML 
61:	ILLPISISIE YLHRFKTFSA GEFLSSLEIG VNMYGSSFKC AFTLIGFKKR QEAKVLLDQL 
121:	DKRCLSDKER STVHRYVAMG NFFDILYHIF YSTFVVMNFP YFLLERRHAW RMYFPYIDSD 
181:	EQFYISSIAE CFLMTEAIYM DLCTDVCPLI SMLMARCHIS LLKQRLRNLR SKPGRTEDEY 
241:	LEELTECIRD HRLLLDYVDA LRPVFSGTIF VQFLLIGTVL GLSMINLMFF STFWTGVATC 
301:	LFMFDVSMET FPFCYLCNMI IDDCQEMSNC LFQSDWTSAD RRYKSTLVYF LHNLQQPITL 
361:	TAGGVFPISM QTNLAMVKLA FSVVTVIKQF NLAERFQ