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1.A.69.1.1
Heteromeric odorant receptor, OR (Sato et al., 2008). OR22a senses fruit-derived esters. These olfactory receptors may have 3-d structures resembling animal rhodopsins, human citronellic terpenoid receptors, OR1A1 and OA1A2 and the mouse eugenol receptor, OR-EG (Ramdya and Benton, 2010). Molecular modelling of oligomeric states of DmOR83b has been reported (Harini and Sowdhamini, 2012).  Recombinant receptor together with the co-receptor, Orco, has been overproduced, purified and reconstituted in a lipid bilayer (Carraher et al. 2013).  Orco (Or83b) forms a dimer that is fully functional for Ca2+ transport, is regulated by calmodulin and interacts normally with Or22a.  The native Orco is therefore probably a dimer (Mukunda et al. 2014).

Accession Number:P81910
Protein Name:OR22b
Length:397
Molecular Weight:46402.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

RefSeq: NP_477425.1   
Entrez Gene ID: 33336   
Pfam: PF02949   
KEGG: dme:Dmel_CG4231   

Gene Ontology

GO:0030425 C:dendrite
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005549 F:odorant binding
GO:0004984 F:olfactory receptor activity
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0050896 P:response to stimulus
GO:0007608 P:sensory perception of smell
GO:0007165 P:signal transduction

References (7)

[1] “A spatial map of olfactory receptor expression in the Drosophila antenna.”  Vosshall L.B.et.al.   10089887
[2] “Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.”  Gao Q.et.al.   10458908
[3] “Nucleotide and copy-number polymorphism at the odorant receptor genes Or22a and Or22b in Drosophila melanogaster.”  Aguade M.et.al.   18922763
[4] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[5] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[6] “A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.”  Clyne P.J.et.al.   10069338
[7] “Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.”  Benton R.et.al.   16402857

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSQFFPHIK EKPLSERVKS RDAFVYLDRV MWSFGWTVPE NKRWDLHYKL WSTFVTLLIF 
61:	ILLPISVSVE YIQRFKTFSA GEFLSSIQIG VNMYGSSFKS YLTMMGYKKR QEAKMSLDEL 
121:	DKRCVCDEER TIVHRHVALG NFCYIFYHIA YTSFLISNFL SFIMKRIHAW RMYFPYVDPE 
181:	KQFYISSIAE VILRGWAVFM DLCTDVCPLI SMVIARCHIT LLKQRLRNLR SEPGRTEDEY 
241:	LKELADCVRD HRLILDYVDA LRSVFSGTIF VQFLLIGIVL GLSMINIMFF STLSTGVAVV 
301:	LFMSCVSMQT FPFCYLCNMI MDDCQEMADS LFQSDWTSAD RRYKSTLVYF LHNLQQPIIL 
361:	TAGGVFPISM QTNLNMVKLA FTVVTIVKQF NLAEKFQ