TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.69.1.1
Heteromeric odorant receptor, OR (Sato et al., 2008). OR22a senses fruit-derived esters. These olfactory receptors may have 3-d structures resembling animal rhodopsins, human citronellic terpenoid receptors, OR1A1 and OA1A2 and the mouse eugenol receptor, OR-EG (Ramdya and Benton, 2010). Molecular modelling of oligomeric states of DmOR83b has been reported (Harini and Sowdhamini, 2012).  Recombinant receptor together with the co-receptor, Orco, has been overproduced, purified and reconstituted in a lipid bilayer (Carraher et al. 2013).  Orco (Or83b) forms a dimer that is fully functional for Ca2+ transport, is regulated by calmodulin and interacts normally with Or22a.  The native Orco is therefore probably a dimer (Mukunda et al. 2014).

Accession Number:P81918
Protein Name:OR43b
Length:403
Molecular Weight:46626.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

RefSeq: NP_523656.2   
Entrez Gene ID: 35743   
Pfam: PF02949   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-003322-MONOMER   
KEGG: dme:Dmel_CG1785   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005549 F:odorant binding
GO:0004984 F:olfactory receptor activity
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0050896 P:response to stimulus
GO:0007608 P:sensory perception of smell
GO:0007165 P:signal transduction

References (4)

[1] “Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.”  Gao Q.et.al.   10458908
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.”  Clyne P.J.et.al.   10069338

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MFGHFKLVYP APISEPIQSR DSNAYMMETL RNSGLNLKND FGIGRKIWRV FSFTYNMVIL 
61:	PVSFPINYVI HLAEFPPELL LQSLQLCLNT WCFALKFFTL IVYTHRLELA NKHFDELDKY 
121:	CVKPAEKRKV RDMVATITRL YLTFVVVYVL YATSTLLDGL LHHRVPYNTY YPFINWRVDR 
181:	TQMYIQSFLE YFTVGYAIYV ATATDSYPVI YVAALRTHIL LLKDRIIYLG DPSNEGSSDP 
241:	SYMFKSLVDC IKAHRTMLNF CDAIQPIISG TIFAQFIICG SILGIIMINM VLFADQSTRF 
301:	GIVIYVMAVL LQTFPLCFYC NAIVDDCKEL AHALFHSAWW VQDKRYQRTV IQFLQKLQQP 
361:	MTFTAMNIFN INLATNINVA KFAFTVYAIA SGMNLDQKLS IKE