TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.4.7.1
The Bin binary toxin, BinAB.  BinA is a toxic P42 protein (protein of 42 KDa) of 362 aas.  The 3-d structure of BinB (448 aas; 1.75 Å resolution) is available; it has two domains, an N-terminal sugar-binding lectin-like domain, and a C-terminal aerolysin-like β-barrel pore-forming domain. Although it shows low sequence identity with other members of the family, it is a member of the Aerolysin Family (Srisucharitpanit et al. 2014).  Protoxin subunits only form monomers, but in vitro activated toxin forms heterodimers. Maximal toxicity to mosquito larvae is achieved when the two subunits, BinA and BinB, are in a 1:1 molar ratio (Surya et al. 2016). An aromatic residue cluster in the C-terminal domain of BinB is critical for toxin insertion in membranes (Chooduang et al. 2018).

Accession Number:P81935
Protein Name:P42 component of the binary toxin
Length:362
Molecular Weight:40973.00
Species:Lysinibacillus sphaericus [1421]
Substrate molecule

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	SFIPTEGKYI RVMDFYNSEY PFCIHAPSAP NGDIMTEICS RENNQYFIFF PTDDGRVIIA 
61:	NRHNGSVFTG EATSVVSDIY TGSPLQFFRE VKRTMETYYL AIQNPESATD VRALEPHSHE 
121:	LPSRLYYTNN IENNSNILIS NKEQIYLTLP SLPENEQYPK TPVLSGIDDI GPNQSEKSII 
181:	GSTLIPCIMV SDFISLGERM KTTPYYYVKH TQYWQSMWSA LFPPGSKETK TEKSGITDTS 
241:	QISMTDGINV SIGADFGLRF GNKTFGIKGG FTYDTKTQIT NTSQLLIETT YTREYTNTEN 
301:	FPVRYTGYVL ASEFTLHRSD GTQVNTIPWV ALNDNYTTIA RYPHFASEPL LGNTKIITDD 
361:	QN