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| Accession Number: | Q02094 |
| Protein Name: | Rhesus blood group-associated glycoprotein aka RhAG |
| Length: | 409 |
| Molecular Weight: | 44198.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 10 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | ammonium, methylamine, ethylamine, carbon dioxide |
Cross database links:
| RefSeq: | NP_000315.2 |
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| Entrez Gene ID: | 6005 |
| Pfam: | PF00909 |
| OMIM: |
180297 gene 268150 phenotype |
| KEGG: | hsa:6005 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0051739
F:ammonia transmembrane transporter activity
GO:0008519
F:ammonium transmembrane transporter activity
GO:0030506
F:ankyrin binding
GO:0015696
P:ammonium transport
GO:0015670
P:carbon dioxide transport
GO:0006873
P:cellular ion homeostasis
GO:0055085
P:transmembrane transport
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References (13)[1] “Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression.” Ridgwell K.et.al. 1417776 [2] “The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease.” Huang C.-H.et.al. 9442063 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [5] “Identification of 5' flanking sequence of RH50 gene and the core region for erythroid-specific expression.” Iwamoto S.et.al. 9473510 [6] “Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.” Avent N.D.et.al. 3146980 [7] “The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast.” Marini A.-M.et.al. 11062476 [8] “Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter.” Westhoff C.M.et.al. 11861637 [9] “Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein.” Westhoff C.M.et.al. 14966114 [10] “Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency.” Cherif-Zahar B.et.al. 8563755 [11] “A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type.” Hyland C.A.et.al. 9454778 [12] “Rh50 glycoprotein gene and rhnull disease: a silent splice donor is trans to a Gly279-->Glu missense mutation in the conserved transmembrane segment.” Huang C.-H.et.al. 9716608 [13] “Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene.” Huang C.-H.et.al. 10467273
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MRFTFPLMAI VLEIAMIVLF GLFVEYETDQ TVLEQLNITK PTDMGIFFEL YPLFQDVHVM 61: IFVGFGFLMT FLKKYGFSSV GINLLVAALG LQWGTIVQGI LQSQGQKFNI GIKNMINADF 121: SAATVLISFG AVLGKTSPTQ MLIMTILEIV FFAHNEYLVS EIFKASDIGA SMTIHAFGAY 181: FGLAVAGILY RSGLRKGHEN EESAYYSDLF AMIGTLFLWM FWPSFNSAIA EPGDKQCRAI 241: VNTYFSLAAC VLTAFAFSSL VEHRGKLNMV HIQNATLAGG VAVGTCADMA IHPFGSMIIG 301: SIAGMVSVLG YKFLTPLFTT KLRIHDTCGV HNLHGLPGVV GGLAGIVAVA MGASNTSMAM 361: QAAALGSSIG TAVVGGLMTG LILKLPLWGQ PSDQNCYDDS VYWKVPKTR