9.A.64.1.1
The SRP-independent protein to endoplasmic reticulum insertion SND complex, Snd1(877 aas and 0 TMSs), Snd2 (181 aas and 4 TMSs; TMEM208; see 9.B.26) and Snd3 (188 aas and 2 or 3 TMSs). These proteins probably function in an SRP (signal
recognition particle)- and GET (guided entry of tail-anchored proteins)-independent pathway for targeting a broad range of substrate proteins to
the endoplasmic reticulum. The SND pathway functions in parallel to GET in
targeting proteins with downstream hydrophobic motifs (Aviram et al. 2016).
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| Accession Number: | Q04007 |
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| Protein Name: | SRP-independent targeting protein 1 |
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| Length: | 877 |
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| Molecular Weight: | 98331.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein polypeptide chain |
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1: MDTVGTDAAA ASINERRFAQ STSPKVSVKS QDSLFLITYS NMQQTVVQAS LADRYPSLKK
61: LNILLYIDIP TIDYYNDEMT HNKLSRLNKR FKLHRLRNSI AQSFSNTSTA EDNDKFWEEL
121: KSLISSRSTP ENKFDLNVLV SSSGSLRYVE TIRFLVEKLF NSFKDLYVQK KLNLCFQINV
181: SPTSLKWFST FLNAELLNLK IINWQNIGSF TKTIQNSKSL PFKEYYTKLN EKFTGSNQSN
241: GSMQDQTVLD SIVIVTNSTG VKALLTLLSD HPLTSLISQE SIKALHEYSD AVNEDKGDDQ
301: SNTSLKRNSS SLLNFQNSVL TSNKDKSVRI RSLSINRKSN RAHMFKTNES ITTIPSTSIN
361: NLIGQESNLR KQPSGTALHL QSHLHPHSRS QSYSSSNMSR SPSPFPYGKT PSNDELVYDE
421: LNNQINEVQD RAKNEEIVLY NNNNYDDYTK ERGEQEQDRT SYADEYGFNY DDEEGGNEDN
481: YDDDEDDDDD DDDDDESDDE GLSFYAPSIL SRSGSSTDVL SSGIDSMAKN SKETRGRFRS
541: LSLMDPALQK PFNQKFPNSQ QPDSAGASSP KRSTSSNHFT NVYVHDGDFD GTDTINNKKN
601: LSSATLIKRK SLMNRNLAPS ISNGLIPPEF ISRISTPSTS ASSSNSSLND MSTVSNAFSK
661: LLNDTSKKQK FLNSPIPQHT QQASPLLMRN NSNSNLLFEK NLINKSFEEL RRQPSVNLFS
721: TLMNGNMEKN GLALNFKSRT PTDALMANSI KNSNNSSHRL LNLEEEDQIM SGSLPKERED
781: DNDSTNSTIV PNHPDNDNYN DNDNDNNTGI NSNNFNLNLY DDNDSAGFTD VTTEGVKYSN
841: SNSTVTKPVY KKAVTLDLYG EDDMDNMGGW VLGGNAR