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9.A.60.1.1
The U snRNA export complex including: phosphorylated adaptor for RNA export (PHAX/RNUXA), nuclear cap-binding protein-1/2 (NCBP1/NCBP2), and RAN GTPase (see also 9.A.50).

Accession Number:Q09161
Protein Name:Nuclear cap-binding protein subunit 1
Length:790
Molecular Weight:91839.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Nucleus1
Substrate small nuclear RNA

Cross database links:

DIP: DIP-33244N
Entrez Gene ID: 4686   
Pfam: PF02854    PF09088    PF09090   
KEGG: hsa:4686   

Gene Ontology

GO:0005829 C:cytosol
GO:0005845 C:mRNA cap binding complex
GO:0005654 C:nucleoplasm
GO:0030529 C:ribonucleoprotein complex
GO:0005515 F:protein binding
GO:0000339 F:RNA cap binding
GO:0031047 P:gene silencing by RNA
GO:0008334 P:histone mRNA metabolic process
GO:0031124 P:mRNA 3'-end processing
GO:0006370 P:mRNA capping
GO:0006379 P:mRNA cleavage
GO:0006406 P:mRNA export from nucleus
GO:0034660 P:ncRNA metabolic process
GO:0000184 P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0031442 P:positive regulation of mRNA 3'-end processing
GO:0050434 P:positive regulation of viral transcription
GO:0006446 P:regulation of translational initiation
GO:0000387 P:spliceosomal snRNP assembly
GO:0006369 P:termination of RNA polymerase II transcription
GO:0006368 P:transcription elongation from RNA polymerase II promoter
GO:0016032 P:viral reproduction

References (30)

[1] “A nuclear cap binding protein complex involved in pre-mRNA splicing.”  Izaurralde E.et.al.   8069914
[2] “Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein.”  Kataoka N.et.al.   7937105
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “A cap-binding protein complex mediating U snRNA export.”  Izaurralde E.et.al.   7651522
[7] “Interaction between the human nuclear cap-binding protein complex and hnRNP F.”  Gamberi C.et.al.   9111328
[8] “Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.”  Wilson K.F.et.al.   10973943
[9] “Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.”  Ishigaki Y.et.al.   11551508
[10] “Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.”  McKendrick L.et.al.   11340157
[11] “The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.”  Lejeune F.et.al.   12093754
[12] “The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex.”  Chiu S.-Y.et.al.   15059963
[13] “eIF4G is required for the pioneer round of translation in mammalian cells.”  Lejeune F.et.al.   15361857
[14] “CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.”  Hosoda N.et.al.   16186820
[15] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[16] “Human mRNA export machinery recruited to the 5' end of mRNA.”  Cheng H.et.al.   17190602
[17] “Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).”  Balatsos N.A.A.et.al.   16317009
[18] “Molecular composition of IMP1 ribonucleoprotein granules.”  Joeson L.et.al.   17289661
[19] “Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.”  Matsuda D.et.al.   17873884
[20] “SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.”  Ma X.M.et.al.   18423201
[21] “NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.”  Woeller C.F.et.al.   18369367
[22] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[23] “Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.”  Gruber J.J.et.al.   19632182
[24] “A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.”  Kim K.M.et.al.   19648179
[25] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[26] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[27] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[28] “Crystal structure of the human nuclear cap binding complex.”  Mazza C.et.al.   11545740
[29] “Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex.”  Mazza C.et.al.   12374755
[30] “Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.”  Calero G.et.al.   12434151
Structure:
1H2T   1H2U   1H2V   1H6K   1N52   1N54   3FEX   3FEY   5OO6   5OOB   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL EGLAGVLEAD 
61:	LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF GGEFVEAMIR QLKESLKANN 
121:	YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE NFVSVTQEED VPQVRRDWYV YAFLSSLPWV 
181:	GKELYEKKDA EMDRIFANTE SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK 
241:	KDRWQERHIL RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG 
301:	PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH IVEVIFAELF 
361:	QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM RLDTMNTTCV DRFINWFSHH 
421:	LSNFQFRWSW EDWSDCLSQD PESPKPKFVR EVLEKCMRLS YHQRILDIVP PTFSALCPAN 
481:	PTCIYKYGDE SSNSLPGHSV ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN 
541:	PLKIEVFVQT LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM 
601:	IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK HVLKIQKELE 
661:	EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE SAQSEQKNLF LVIFQRFIMI 
721:	LTEHLVRCET DGTSVLTPWY KNCIERLQQI FLQHHQIIQQ YMVTLENLLF TAELDPHILA 
781:	VFQQFCALQA