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|---|---|
| Accession Number: | Q09161 |
| Protein Name: | Nuclear cap-binding protein subunit 1 |
| Length: | 790 |
| Molecular Weight: | 91839.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | small nuclear RNA |
Cross database links:
| DIP: | DIP-33244N |
|---|---|
| Entrez Gene ID: | 4686 |
| Pfam: | PF02854 PF09088 PF09090 |
| KEGG: | hsa:4686 |
Gene Ontology
GO:0005829
C:cytosol
GO:0005845
C:mRNA cap binding complex
GO:0005654
C:nucleoplasm
GO:0030529
C:ribonucleoprotein complex
GO:0005515
F:protein binding
GO:0000339
F:RNA cap binding
GO:0031047
P:gene silencing by RNA
GO:0008334
P:histone mRNA metabolic process
GO:0031124
P:mRNA 3'-end processing
GO:0006370
P:mRNA capping
GO:0006379
P:mRNA cleavage
GO:0006406
P:mRNA export from nucleus
GO:0034660
P:ncRNA metabolic process
GO:0000184
P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0031442
P:positive regulation of mRNA 3'-end processing
GO:0050434
P:positive regulation of viral transcription
GO:0006446
P:regulation of translational initiation
GO:0000387
P:spliceosomal snRNP assembly
GO:0006369
P:termination of RNA polymerase II transcription
GO:0006368
P:transcription elongation from RNA polymerase II promoter
GO:0016032
P:viral reproduction
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References (30)[1] “A nuclear cap binding protein complex involved in pre-mRNA splicing.” Izaurralde E.et.al. 8069914 [2] “Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein.” Kataoka N.et.al. 7937105 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “A cap-binding protein complex mediating U snRNA export.” Izaurralde E.et.al. 7651522 [7] “Interaction between the human nuclear cap-binding protein complex and hnRNP F.” Gamberi C.et.al. 9111328 [8] “Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.” Wilson K.F.et.al. 10973943 [9] “Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.” Ishigaki Y.et.al. 11551508 [10] “Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.” McKendrick L.et.al. 11340157 [11] “The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.” Lejeune F.et.al. 12093754 [12] “The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex.” Chiu S.-Y.et.al. 15059963 [13] “eIF4G is required for the pioneer round of translation in mammalian cells.” Lejeune F.et.al. 15361857 [14] “CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.” Hosoda N.et.al. 16186820 [15] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [16] “Human mRNA export machinery recruited to the 5' end of mRNA.” Cheng H.et.al. 17190602 [17] “Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).” Balatsos N.A.A.et.al. 16317009 [18] “Molecular composition of IMP1 ribonucleoprotein granules.” Joeson L.et.al. 17289661 [19] “Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.” Matsuda D.et.al. 17873884 [20] “SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.” Ma X.M.et.al. 18423201 [21] “NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.” Woeller C.F.et.al. 18369367 [22] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [23] “Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.” Gruber J.J.et.al. 19632182 [24] “A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.” Kim K.M.et.al. 19648179 [25] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [26] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 | |
| Structure: | |
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| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL EGLAGVLEAD 61: LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF GGEFVEAMIR QLKESLKANN 121: YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE NFVSVTQEED VPQVRRDWYV YAFLSSLPWV 181: GKELYEKKDA EMDRIFANTE SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK 241: KDRWQERHIL RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG 301: PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH IVEVIFAELF 361: QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM RLDTMNTTCV DRFINWFSHH 421: LSNFQFRWSW EDWSDCLSQD PESPKPKFVR EVLEKCMRLS YHQRILDIVP PTFSALCPAN 481: PTCIYKYGDE SSNSLPGHSV ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN 541: PLKIEVFVQT LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM 601: IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK HVLKIQKELE 661: EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE SAQSEQKNLF LVIFQRFIMI 721: LTEHLVRCET DGTSVLTPWY KNCIERLQQI FLQHHQIIQQ YMVTLENLLF TAELDPHILA 781: VFQQFCALQA