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3.A.27.1.1
ER membrane protein insertase complex of ten recognized proteins, EMC1 - 10 (Guna et al. 2018).  Inserts C-terminal moderately hydrophobic TMSs of tail anchored (TA) proteins into the endoplasmic reticular membrane (Guna et al. 2018). EMC also inserts the first N-terminal TMS of G-proteins and some receptors co-translationally and cooperates with the Sec61 translocon to ensure accurate topogenesis of many membrane proteins (Chitwood et al. 2018). Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects (Marquez et al. 2020). The high resolution 3-d structure of this EMC complex has been determined (O'Donnell et al. 2020). EMC10 plays a regulatory role in the ER membrane complex, opposing the transmembrane-domain insertion activity of the complex (Coukos et al. 2021).

Accession Number:Q15006
Protein Name:ER membrane protein complex subunit 2
Length:297
Molecular Weight:34834.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate

Cross database links:

Structure:
6WW7   6Y4L   6Z3W     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD DIWIIYEQVM 
61:	IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN 
121:	TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE 
181:	LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA 
241:	SNPKASAKTK KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS