1.A.34.1.4 SpoIIQ-SpoIIIAH complex spanning the two membranes of the mother cell and the prespore. Inhibiting SpoIIQ, SpoIIIAA, or SpoIIIAH function apparently prevents the formation of infectious C. difficile spores and thus disease transmission (Fimlaid et al. 2015). spoIIQ or
spoIIIAH mutants that complete engulfment are impaired in
post-engulfment, forespore and mother cell-specific gene expression, in agreement with a channel-like function (Serrano et al. 2016).
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Accession Number: | Q18B63 |
Protein Name: | Stage III sporulation protein AH |
Length: | 229 |
Molecular Weight: | 25906.00 |
Species: | Peptoclostridium difficile (strain 630) [272563] |
Number of TMSs: | 1 |
Substrate |
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1: MKFNYKGRGF VIITLTAMLV VVGTVNYQLS KKSLLETSKE FKAYEEAQLQ KNTDDSDSSK
61: TEDSSNVDKQ GGKESADIDI VDSKASKVKE KATETSKEIK AQLSSEKNMK KASYILDMKM
121: NREKQRNELV QDLNEMINNP STTEESRKEA SNMKLNIVKI QEKELQIENL LSTKGYEEAL
181: VYISDNKVNV VVNEAKLEKK DAAKIFDLVA EQANVKYENI KLTNNNSNK